特异性生物标记物DOG1在胃肠间质瘤中的表达  

Expression of DOG1 in gastrointestinal stromal tumor and its significance

作　　者：杨军[1] 刘妮[1] 康安静[1] 靳耀锋[1] 苏宝山[1] 陈晓黎[1] 

机构地区：[1]西安交通大学医学院第二附属医院病理科,西安710004

出　　处：《诊断病理学杂志》2013年第5期282-285,共4页Chinese Journal of Diagnostic Pathology

基　　金：教育部"长江学者和创新团队发展计划"创新团队(IRT1171)资助

摘　　要：目的探讨DOG1在胃肠间质瘤(GISTs)中的表达及其临床意义,并与CD117、CD34、SMA和S-100进行比较。方法收集68例GISTs病例,采用免疫组化SP法检测DOG1、CD117、CD34、SMA和S-100的表达,以瘤旁胃肠肌层组织和子宫平滑肌瘤、神经纤维瘤、纤维瘤作为对照。结果 68例GISTs中,DOG1、CD117、CD34阳性表达率分别为97.1%(66/68)、89.7%(61/68)、82.4%(56/68),DOG1和CD117的阳性率均显著高于CD34阳性率(P<0.05),且DOG1阳性率也显著高于CD117阳性率(P<0.05)。SMA和S-100在GISTs中均为(-)。结论 DOG1是胃肠间质瘤特异性生物标记,联合检测DOG1、CD117、CD34、SMA和S-100蛋白的表达对于确诊GISTs具有重要价值。Objective To investigate the expression of DOGI, CDl17, and CD34 in gastrointestinal stromal tumors （GISTs）. Methods A total of 68 cases of GISTs were studied by histological evaluation along with immunohistochemical analysis of DOG1, CDllT, CD34, SMA and S-100. Results Among 68 GISTs cases, DOG1 expression was positive in 97. 1% （66 /68）, CDll7 in 89.7% （61/68） and CD34 in 82.4% （56/68）. The positive rates of DOG1 were significantly higher than those of CD117 and CD34 （P 〈 0. 05 ）. SMA and S-100 were usually absent or weakly expressed. Conclusions These results indicate that the expression of DOG1 and CDII7 is observed in a majority of GISTs cases. Combined DOG1, CD117, CD34, SMA and S-100 immunohistochemical staining can be used in diagnosis and differential diagnosis of GISTs, which will likely improve the diagnostic accuracy of GISTs.

关 键 词：胃肠间质瘤 C-KIT DOG1 CD117 

分 类 号：R735.2[医药卫生—肿瘤]