不同饮水类型与结直肠癌发病率的流行病学研究  

An epidemiological study on the incidence rates of colorectal cancer through different drinking water sources

作　　者：陈坤[1] 周伦[2] 沈高飞 余海[2] 

机构地区：[1]浙江大学公共卫生学院流行病学研究室,杭州310006 [2]浙江大学医学院肿瘤研究所 [3]海宁市肿瘤防治研究所

出　　处：《中华流行病学杂志》2000年第4期249-252,共4页Chinese Journal of Epidemiology

基　　金：卫生部自然科学基金资助!(961350)

摘　　要：目的　探索不同饮水类型与结直肠癌发病率之间的关系。方法　随机抽取了浙江省海宁市的 8个乡镇为研究区 ,应用回顾前瞻性研究方法 ,分别对不同饮水类型的结肠、直肠癌发病率进行分析并作相对危险度 (RR)估计。结果　饮用井水、自来水、河水和池塘水者的结直肠癌发病率男性分别为 3 .19/ 10万、7.99/ 10万、45 .0 6 / 10万和 12 6 .0 4/ 10万 ;女性分别为 3 .0 6 / 10万、5 .17/ 10万、6 3 .43/ 10万和 81.76 / 10万 ,均呈依次递增趋势 (P <0 .0 1)。RR分析显示 ,饮用池塘水、河水者 ,罹患结直肠癌的危险性分别达到 14.13和 39.5 1(男性 )以及 2 0 .73和 2 6 .72 (女性 )。结论　不同饮水类型的结直肠癌发病率有差异 ,饮用池塘水。Objective In order to identify the association of incidence rates of colorectal cancer and different drinking water sources. Methods With the retrospective cohort method, 8 villages ortownships in Haining city were randomly selected as the study area where a total 408 cases were collected during 1977 to 1996. The incidence rates according to the drinking water sources were calculated by sex and sites of the cancer. The RR estimates were given to each sex and site by comparing to that in well water source. Results The incidence rates of colorectal cancer by sequence of the sources were shown as follows drinking water: (male: pool water 126.04 /105; female: 81.76 /105),river water(male: 45.06 /105; female: 63.43 /105), tap water (male: 7.99 /105; female: 5.17 /105) and well water(male: 3.19 /105 ; female: 3.06 /105). All of them were statistically significance through χ2 trend tests. Poisson test was used to have found the differences of incidences of colorectal cancer between different drinking water sources(P< 0.01 ). RR estimates showed that the risk of colorectal cancer with pool or river water sources were 7 times higher than that with well water. Conclusion Study of this kind might uncover the differences which accounted for the associations between the drinking water sources and colorectal cancer.

关 键 词：结直肠肿瘤 饮用水类型 发病率 流行病学 

分 类 号：R73-31[医药卫生—肿瘤]