血浆溶血磷脂酸与抑郁症的相关性研究  

A correlation study between plasma lysophosphatidic acid and depression

作　　者：李再忠 胡珍玉 罗贤海 高树贵 杨红英 谢曙光 

机构地区：[1]宁波市康宁医院,宁波315201

出　　处：《现代实用医学》2013年第4期374-375,381,共3页Modern Practical Medicine

基　　金：宁波市医学科技基金项目(200541)

摘　　要：目的探讨血浆溶血磷脂酸浓度与抑郁症的关系。方法对对照组和抑郁症组进行基线比较;用抗抑郁药物西酞普兰片治疗抑郁症患者,同时采用抽提法测量血浆溶血磷脂酸浓度;并于治疗前后做脑诱发电位P300、抑郁量表、焦虑量表及认知量表抑郁评定与临床疗效观察。结果治疗前抑郁症组抑郁量表总分和脑诱发电位P300异常率均比对照组高(均<0.01);抑郁症患者治疗4、8周后抑郁相关量表及脑诱发电位P300检查证明病情显著改善,血浆溶血磷脂酸浓度比治疗前明显降低(均<0.01)。结论血浆溶血磷脂酸浓度与抑郁症的有着密切的关系,为抑郁症的疗效监测提供理论指导。Objective To investigate the relationship between plasma lysophosphatidic acid （LPA） and depression level. Methods The index base line of control and case group were analyzed. Blood samples obtained from Cital- opram treated case group were to identify lysophosphatidic acid concentration by the extraction method. Brain evoked potentials P300, Hamilton depressive scale （HAMD）, Hamilton anxiety scale. Results Abnormal rate of brain evoked potentials P300 and HAMD score were higher in the case group （P ~ 0.01）. Depressive symptom were sig- nificantly improved while plasma lysophosphatidic acid concentration were obviously reduced after treatment of Cit- alopram for four and eight weeks （P ~ 0.01）. Conclusions There is a correlation between plasma lysophosphatidic acid concentration and depression level, which provides theoretical guidance for effect monitoring of depression cure.

关 键 词：溶血磷脂素类 抑郁症 药物疗法 西酞普兰片 

分 类 号：R749.4[医药卫生—神经病学与精神病学]