经内镜食管曲张静脉测压及生长抑素和奥曲肽的降压作用研究  

Manometry of esophageal variceal pressure after use of somatostatin and octreotide

作　　者：吴云林[1] 王玲玲[1] 徐志红[1] 陆和平[2] 杨根妹 施华秀[1] 冯莉 

机构地区：[1]上海第二医科大学附属瑞金医院消化科,200025 [2]上海浦东新区人民医院消化科 [3]上海普陀区中心医院消化科 [4]山西省太钢总医院消化科

出　　处：《中华消化内镜杂志》2000年第4期208-210,共3页Chinese Journal of Digestive Endoscopy

摘　　要：目的测定肝硬化食管曲张静脉内压力(IOVP) ,比较生长抑素及奥曲肽降压效应。方法生长抑素组8例 ,奥曲肽组10例 ,均经内镜作食管曲张静脉穿刺测压 ,分别静脉内注射生长抑素0.25mg及奥曲肽0.1mg,测压5分钟。结果生长抑素组IOVP降低49.8 %(P<0.01) ,奥曲肽组IOVP降低29.9 %(P<0.05)。结论两组患者对生长抑素和奥曲肽均有反应性 ,能有效降低肝硬化门脉高压患者的IOVP值。Objective Assessment was made of (1) intra-oesophageal-variceal-pressure (IOVP); (2) IOVPs following administration of somatostatin and octreotide. Methods 18 consecutive cirrhotic patients were randomized andstudied with somatostatin (n=8) and octreotide (n=10). Endoscopic manometry of IOVP for 5 minutes was sustained after intravenous bolus injection of 0.25 mg ofsomatostatin and 0.1 mg of octreotide. Results IOVP decreased by 49.8 percent(P<0.01) with somatostatin and by 29.5 percent (P<0.05) with octreotide. Conclusion It is evident that IOVP in cirrhotic patient with portal hypertension can be reduced markedly with either somatostatin or octreotide.

关 键 词：食管静脉曲张 生长抑素 奥曲肽 静脉测压 内窥镜 

分 类 号：R571.3[医药卫生—消化系统]