肝癌患者术后生存质量相关多因素Cox模型分析  

Application of Multiple Factors CoX Model on the Quality of Life of Patients with Hepatocellular Carcinoma after Operation

作　　者：秦骏[1] 周全博[1] 罗蒙[1] 

机构地区：[1]上海交通大学医学院附属仁济医院普外科,上海200127

出　　处：《河北医学》2013年第7期971-974,共4页Hebei Medicine

摘　　要：目的:通过多因素Cox模型分析,探讨影响肝癌患者术后生存质量的主要因素。方法:选取我院肝胆外科收治的原发性肝癌行根治性肝癌切除术进行治疗的患者110例,并对其临床资料进行回顾性分析,先对可能影响患者术后生存质量的因素进行单因素分析,再将单因素分析结果进行多因素Cox模型分析以找出影响原发性肝癌患者术后生存质量的主要因素。结果:本文患者第一年复发率为39.1%,生存率为77.3%;第三年复发率68.2%,生存率39.1%;第五年复发率82.7%,生存率23.6%。单因素分析结果显示:患者的年龄、肿瘤包膜的形成、包膜的浸润、微血管的浸润、门静脉癌栓、肿瘤直径(>5cm)、术后肿瘤早期复发和患者术后的生存质量有关。多因素Cox模型分析结果显示:微血管的浸润、门静脉癌栓以及肿瘤早期的复发对患者术后的生存质量有着显著的影响。结论:原发性肝癌患者的早期诊断和治疗、以及术后注意定期复查,尽早发现和处理复发的肿瘤能够提高患者术后的生存质量。Objective： To investigate the main factors influencing the quality of life of patients with hep- atoeellular carcinoma after operation through Cox model analysis. Method： 110 patients with hepatoeellular carcinoma were selected from department of hepatobiliary surgery in our hospital, they received the treatment of radical hepatectomy, and the clinical data of whom was retrospectively analyzed, then the result of single factor analysis were set for multiple factors Cox analysis to find out the main factors, which affect the quality of life of patients with hepatocellular carcinoma after operation. Result： The recurrence rate and survival rate in the first year were 39.1% and 77.3%, in the third year were 68.2% and 39.1%, in the fifth year were 82.7% and 23.6%, respectively. The results of single factor analysis showed： the patient＇s age, tumor cap- sule formation, capsular infiltration, vascular invasion, tumor thrombus in the portal vein, tumor diameter （〉5 cm ） , and postoperative early tumor recurrence show correlation with quality of patients with hepatocellu- lar carcinoma after operation. Multivariate Cox model analysis showed： microvaseular invasion, portal vein tumor thrombus and tumor recurrence cant influence on regularly review, in patients with hepatocellular the quality of life. Conclusion： Early diagnosis early detection and treatment of recurrence of the patients with hepatocellular carcinoma after operation. carcinoma after operation had the signifi- and treatment, postoperative attention to tumor can improve the quality of life of patients with hepatocellular carcinoma after operation.

关 键 词：原发性肝癌 根治性切除术 生存质量 多因素Cox模型分析 

分 类 号：R735.7[医药卫生—肿瘤]