McAb共刺激PBLs淋巴细胞在培养体系中的状态及超微结构的研究  

Ultrastructural Study of PBLs Costimulated with McAb in Culture System

作　　者：郭伟鹏 张康 林青 陈永雄 李俊云 罗利琼[2] 林月霞[2] 邹奕 

机构地区：[1]广西梧州市人民医院,广西梧州543000 [2]广东药学院分子生物学研究室

出　　处：《广东药学院学报》2000年第3期191-193,共3页Academic Journal of Guangdong College of Pharmacy

摘　　要：通过用抗CD3,CD2 8+CD80McAb激活健康人的PBLs,并以PHA ,IL 2 ,PBLs为对照组 ;对各组不同时间段的淋巴细胞超微结构进行观察。结果提示 :CD3及CD2 8+CD80除刺激淋巴细胞增殖外 ,也能使淋巴细胞活化 ;细胞表现为胞体增大 ,细胞器增多 ,具有粗大的绒毛和突出伪足 ,并可见单核细胞吞噬活跃。In this paper,the human healthy PBLs was activated with Anti CD3 and CD28+CD80 McAb,with PHA, IL 2 and PBLs as controls. During different periods of activation, the ultrastructure of lymphocytes was observed under trans electron microscope. The result indicated that beside stimulating lymphocytes proliferation, CD3, CD28+CD80 McAb could also activated lymphocytes.

关 键 词：MCAB共刺激 淋巴细胞 超微结构 PBLS 免疫疗法 

分 类 号：R730.5[医药卫生—肿瘤]