大肠癌术后肝转移高危因素研究  

Analysis of high risk factors of liver metastasis in patients with postoperative colorectal cancer

作　　者：蒋玥[1] 王阿曼[2] 张洁[2] 班丽英[2] 周涛[2] 

机构地区：[1]河北省沧州中西医结合医院肿瘤内科,061001 [2]大连医科大学附属第一医院肿瘤内科

出　　处：《国际肿瘤学杂志》2013年第5期392-395,共4页Journal of International Oncology

摘　　要：目的筛选大肠癌根治术后发生肝转移的高危因素，并建立数学模型。方法分析168例患者5年随访资料，logistics回归明确术后肝转移的高危因素，ROC检验建立数学模型。结果全组3年和5年肝转移发生率为25．0％和33．3％，高危因素为淋巴结转移、肿瘤浸润深度、组织学分级及术前肿瘤标志物水平，数学模型为logit（P）=-0．931＋0．973×淋巴结转移＋0．302×肿瘤浸润深度＋0．637X组织学分级＋0．042×术前肿瘤标志物水平。结论大肠癌术后肝转移的高危因素为淋巴结转移、肿瘤浸润深度、组织学分级及术前肿瘤标志物水平，并可建立数学模型。Objective To screen the risk factors of liver metastasis in patients with postoperative colorectal cancer and to set up a mathematic model. Methods One hundred and sixty-eight patients received radical surgery were retrospectively analyzed. Logistics model regression was used to identify the risk factors and ROC test to complete a mathematic model. Results The 3 and 5-year incidence rate of liver metastasis was 25.0% and 33.3% , respectively. The risk factors of liver metastasis were lymph node metastasis （LNM）, tumor invasive depth （ TID）, histological grading （G） and preoperative serum tumor markers （ PSMs ）. The mathematic model was： logit （P） = - 0. 931 ＋ 0. 973 x LNM ＋ 0. 302 x TID ＋ 0. 637 x G ＋ 0. 042 x PSMs. Conclusion The risk factors of liver metastasis were LNM, TID, G and PSMs, and the mathematic model could be set up.

关 键 词：结直肠肿瘤 肿瘤转移 肝 危险因素 

分 类 号：R735.34[医药卫生—肿瘤]