甲状腺球蛋白测定与^131碘全身扫描对分化型甲状腺癌^131碘治疗后的随访价值 郭一玲 张英男 陈佐伟 冯 程 辛镇祓  

Follow-up value of the detection of thyroglobulin and whole body scan by ^131I for thyroid cancer after treatment by ^131I

作　　者：郭一玲[1] 张英男[1] 陈佐伟[1] 冯程[1] 辛镇祓[1] 

机构地区：[1]深圳市人民医院乳外科,广东省深圳518020

出　　处：《中国基层医药》2013年第9期1281-1283,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：广东省深圳市科技计划项目（201003017）

摘　　要：目的 探讨甲状腺球蛋白（Tg）测定与^131碘全身扫描（WBS）对分化型甲状腺癌（DTC）^131碘治疗后的随访价值。方法 对164例DTC^131碘治疗后,采用Tg测定与^131碘全身扫描作为随访方法,观察DTC复发或转移情况。结果 血清Tg测定与^131碘WBS对DTC复发或转移诊断有高度的一致性（kappa值0.587,SE=0.076,P〈0.01）,但会出现假阴性。结论 在DTC^131碘治疗后进行随访的过程中,测定血清Tg时必须同时做血清TgAb测定,以防假阴性出现。Objective To explore the value of follow-up of serum TSH stimulating thyroglobulin（Tg）test and ^131I whole body scan（WBS） in patients with differentiated thyroid cancer（DTC） who were treated by ^131I.Methods By SPSS software,Kappa test was performed between results of serum Tg,TgAb test and WBS for diagnosis of persistent/recurrent DTC.Results Consistency test of TSH stimulating Tg,TgAb and ^131I WBS for diagnostic persistent/recurrent or metastasis of DTC：kappa value=0.587,SE=0.076,P〈0.01.Although the results showed that two measurements appeared definite consistency,it is dissatisfactory.Conclusion Serum TSH stimulating Tg test and ^131I whole body scan（WBS） are important follow-up tools for patients with DTC.Because of Tg interfering it is necessary to performed TgAb test simultaneously,when Tg test was performed.Especially ^131I WBS do is not absent because false negative would be able to appeared in single serum TSH stimulating Tg and TgAb test.

关 键 词：甲状腺癌 免疫球蛋白 甲状腺刺激 碘 

分 类 号：R736.1[医药卫生—肿瘤]