肾上腺原始神经外胚层肿瘤二例诊治分析并文献复习  

The diagnosis and treatment analysis for primitive neuroectodermal tumor of the adrenal gland：2 cases report and literature review

作　　者：裴再军 付海英 

机构地区：[1]桐乡市中医医院泌尿外科,浙江省桐乡314500 [2]桐乡市中医医院病理科,浙江省桐乡314500

出　　处：《中国基层医药》2013年第11期1645-1647,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨国内外肾上腺原始神经外胚层肿瘤（PNET）的诊断和治疗。方法 回顾性分析桐乡市中医医院诊治的2例肾上腺PNET患者的临床资料,并结合相关国内外文献探讨其诊断和治疗方法。结果 B超、CT检查示两例患者肾上腺区边界不清的囊实性软组织肿块,最大直径分别约3 cm和15 cm。2例患者均行手术治疗。术后病理及免疫组化确诊为肾上腺PNET。患者1尚无肿瘤复发证据。患者2随访3个月后发现腹膜后广泛淋巴结转移。6个月后死亡。结论 肾上腺PNET临床罕见,恶性程度高且预后不良,确诊主要依靠病理和免疫组化,治疗提倡多手段综合治疗。Objective To explore the diagnosis and treatment for primitive neuroectodermal tumor of the adrenal gland.Methods The clinical data of 2 patients with primitive neuroectodermal tumor of the adrenal gland were retrospectively analyzed.Literatures about diagnosis and treatment of primitive neuroectodermal tumor arising from the adrenal gland were also reviewed.Results B type ultrasonography and computer tomography scans showed a cystic and solid soft tissue masses about 3cm（patient 1） and 15cm（patient 2） in maximum diameter with rough border.Surgeries were performed successfully in 2 patients.The diagnosis of primitive neuroectodermal tumor arising from the adrenal gland was confirmed by histopathology and immunohistochemistry.During follow up,evidences of tumor recurrence were not found in the first patient.However,the second patient had diffuse retroperitoneal lymph node metastasis 3 months after surgery.Then,the patient died 6 months after surgery.Conclusion The primitive neuroectodermal tumor of the adrenal gland is extremely rare with highly malignant and poor prognosis.Its diagnosis is based on histopathology and immunohistochemistry.Multimodal therapeutic regimens including surgery,combination with chemotherapy and radiotherapy were recommended.

关 键 词：肾上腺 神经 外胚层 肿瘤 诊断 治疗 

分 类 号：R736.6[医药卫生—肿瘤]