蛋白质组学在辐射相关肿瘤研究中的应用  

Application of proteomics in radiation-related cancer research

作　　者：生卫红[1] 王明科(综述)[2] 冉新泽(审校)[3] 

机构地区：[1]济南军区青岛第一疗养院,266071 [2]海军医学研究所 [3]第三军医大学令军复合伤研究所创伤、烧伤与复合伤国家重点实验室

出　　处：《肿瘤研究与临床》2013年第5期358-360,共3页Cancer Research and Clinic

基　　金：基金项目：国家重点基础研究发展计划（2012CB518103、2005CB522605）

摘　　要：辐射的致癌效应是人类最严重的辐射远期效应.辐射引起的肿瘤主要有白血病、甲状腺癌、肺癌、乳腺癌、胃癌、结肠癌、多发性骨髓瘤等.蛋白质作为生命活动的执行者,随着后基因组时代的到来,人们的研究视野逐渐从基因组学转向蛋白质组学,并成为生命科学研究的热点之一.蛋白质组学以基因组编码的所有蛋白质为研究对象,可从整体水平研究肿瘤在不同阶段和条件下蛋白质的组成及变化规律,已被用于肿瘤的分子标志物检测、发病机制、早期诊断、治疗、预防及预后等方面的研究.文章探讨蛋白质组学在几类辐射相关肿瘤研究中的应用.Radiation-induced cancer is the most severe remote effect caused by radiation in human.Radiation-induced cancer includes leukemia,multiple myeloma,thyroid carcinoma,lung cancer,breast cancer,gastric cancer,and colon cancer.As protein is the executor of life activities,more and more research has been transfered from genomics to proteomics with the coming of post-genome era,and proteomics has became one of the hot research areas in life science.Proteomics is to study all expressed proteins＇ function encoded by genome sequences,and it provides a good way to study the composition and variation features in different stages and treatment conditions of cancer from the whole level.Therefore,proteomics has been widespreadly applicated in many fields of cancer research such as finding tumor markers,discovering molecular mechnism,early diagnosis,therapeutic efficacy assessment,cancer prevention and prognosis,etc.This article reviews the recent application of proteomics in some kinds of radiation-induced cancer.

关 键 词：辐射相关肿瘤 蛋白质组学 分子标志物 诊断 治疗 

分 类 号：R730[医药卫生—肿瘤]