甘露聚糖肽联合卡铂腹腔灌注治疗老年女性复发性卵巢上皮癌伴恶性大量腹腔积液近期疗效观察  

Short-term effective observation on abdominal cavity perfusion with mannatide and carboplatin in treating old women with relapsed ovarian epithelial cancer complicating massive malignant seroperitoneum

作　　者：李亚莉[1] 周恒根[1] 倪敬忠 刘兰芳[1] 程燕[1] 李华年[1] 

机构地区：[1]邳州市人民医院肿瘤内科,江苏邳州221300

出　　处：《现代医药卫生》2013年第10期1451-1453,共3页Journal of Modern Medicine & Health

摘　　要：目的观察甘露聚糖肽联合卡铂腹腔灌注治疗老年女性复发性卵巢上皮癌伴恶性大量腹腔积液的近期疗效及不良反应。方法对61例老年女性复发性卵巢上皮癌伴恶性大量腹腔积液患者行腹腔闭式引流,尽量排尽腹腔积液后,随机分为治疗组31例和对照组30例。治疗组应用甘露聚糖肽联合卡铂腹腔灌注,对照组单用卡铂腹腔灌注,比较两组患者的治疗效果及不良反应。结果治疗组完全缓解(CR)9例,部分缓解(PR)16例,总有效率为80.6%(25/31),对照组CR 7例,PR 10例,总有效率为56.7%(17/30),两组比较,差异有统计学意义(P<0.05);治疗组患者生活质量改善率为83.9%(26/31),对照组为73.3%(22/30),两组比较,差异无统计学意义(P>0.05);两组患者骨髓抑制、消化道不良反应等比较,差异无统计学意义(P>0.05),治疗组发热(29.0%,9/31)较对照组(6.7%,2/30)明显(P<0.05),予以对症治疗可缓解。结论甘露聚糖肽联合卡铂治疗卵巢上皮癌伴恶性大量腹腔积液近期疗效较好,不良反应可耐受。Objective To investigate the efficacy and adverse reactions of abdominal cavity perfusion with mannatide and carboplatin in the treatment of old women with relapsed ovarian epithelial cancer complicating massive malignancy seroperitoneum. Methods 61 patients with relapsed ovarian epithelial cancer complicating massive malignancy seroperitoneum were selected and randomly divided into two groups after closed drainage for exhausting seroperitoneum. The treatment group （31 cases） was treated by abdominal cavity perfusion with mannatide and carboplatin, while the control group （30 cases） were treated by only abdominal cavity perfusion with carboplatin. The curative effects and adverse reactions were compared between the two groups. Results In the treatment group ,9 cases got completely recovery（CR）, 16 cases got partial recovery（PR） ,and the total effective rate （CR＋PR） was 80.6% （25/31 ） ;while in the control group, 7 cases got CR, 10 cases got PR, and the total effective rate （CR＋PR） was 56.7% （17/30）. The difference between the two groups had no statistical significance （P〈0.05）. The improvement rate of the quality of life was 83.9% （26/31 ） in the treatment group and 73.3% （22/30） in the control group, there was no statistical difference between the two groups （P〉0.05）. There were no statistical difference in adverse reactions like myelosuppression, gastrointestinal reactions between the two groups （P〉0.05）, and incidence rate of fever in the treatment group was higher than that in the control group （P〈0.05）,which could be recovered by symptomatic treatment. Conclusion The combination of mannatide and carbo- platin has better short-term effect in the treatment of ovarian epithelial cancer complicating malignancy seroperitoneum and its ad- verse reactions are tolerable.

关 键 词：卵巢肿瘤 药物疗法 腹水 药物疗法 甘露聚糖类 投药和剂量 药物疗法 联合 卡铂 投药和剂量 注射 腹腔内 治疗结果 老年人 

分 类 号：R737.31[医药卫生—肿瘤]