4NQO诱发大鼠舌癌变细胞增殖与分化异常的研究  

Experimental Study of Abnormal Cell Proliferation and Differentiation in Rat Tongue Carcinogenesis Induced by 4NQO

作　　者：刘兴坤 何荣根[2] 陈万涛[2] 张志愿[2] 周曾同[2] 周晓健[2] 

机构地区：[1]江苏省苏州市口腔医院,江苏215005 [2]上海第二医科大学附属第九人民医院口腔医学院口腔颌面外科,上海200011

出　　处：《上海口腔医学》2000年第2期67-69,共3页Shanghai Journal of Stomatology

基　　金：国家自然科学基金!(NO.39670787)

摘　　要：目的　阐明口腔癌变细胞增殖与分化异常的表型特征。方法　LSAB免疫组化方法检测 6 9例 4 硝基喹啉 1 氧化物 ( 4NQO)口服诱发大鼠舌癌变各期组织分化标志gp2 30和增殖标志增殖细胞核抗原 (PCNA)的表达。结果　随口腔癌变进展 ,基底上层gp2 30表达逐渐减少 ;基底层PCNA表达逐渐增强。结论　口腔癌变既是细胞增殖异常 。Objective To clarify the phenotypic characteristics of abnormal cell proliferation and differentiation in oral carcinogenesis. Methods The expressions of gp230, a marker of epithelium cell differentiation, and proliferating cell nuclear antigen(PCNA) in rat tongue carcinogenesis induced by 4nitroquinoline1oxide (4NQO) were detected by LSAB immunohistochemical staining. Results With the progress of oral carcinogenesis abnormal proliferation and differentiation patterns were indicated by reduced expression of gp230 and increased expression of PCNA. Conclusion Oral carcinogenesis is the result of mucosa epithelium cell aberrant proliferation and differentiation.[

关 键 词：舌 癌变 gp230 增殖细胞核抗原 

分 类 号：R739.8[医药卫生—肿瘤]