MUM-1在经典型霍奇金淋巴瘤R-S细胞中的表达及其意义  

Expression of MUM-1 of R-S cells in classical Hodgkin lymphoma and its significance

作　　者：李楠[1] 杜金荣[1] 

机构地区：[1]哈尔滨医科大学附属第四医院病理科,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2013年第2期153-155,共3页Journal of Harbin Medical University

摘　　要：目的探讨经典型霍奇金淋巴瘤(CHL)R-S细胞中MUM-1蛋白的表达和意义。方法收集30例CHL,采用免疫组织化学SP法标记MUM-1抗体,观察MUM-1蛋白在CHL中R-S细胞的表达,并比较与CD30、CD15、pax-5表达的差异性。结果 R-S细胞MUM-1的表达强度明显高于CD30和CD15。MUM-1蛋白在全部30例CHL的R-S细胞胞核中阳性表达,阳性率为100%(30/30);CD30、CD15的表达强弱不等,阳性率分别为96.7%(29/30)、73.3%(22/30),pax-5弱阳性表达83.3%(25/30)。结论MUM-1蛋白是经典型霍奇金淋巴瘤R-S细胞高度敏感的标记物,它有助于诊断CHL,其阴性表达具有排除CHL的意义。Objective To explore the expression and significance of MUM-1 of Reed-Sternberg cells （R-S cells） in classical Hodgkin lymphoma （CHL）. Methods MUM-1 in 30 cases of CHL were immunohistochemically stained with SP method. The expression of MUM-1 of R-S cell was observed and compared with the expression of CD30, CD15 and pax-5 in R-S cells. Results In all cases of CHL, the intensity of expression of MUM-1 was significantly higher than that of CD30 and CD15. All 30 cases（ 100% ） of CHL showed an intensely caryon sta- ning, while 29 among them （96.7%） for CD30 and 22（73.3% ） of 30 cases for CD15 showed weak-to-strong expression, and pax-5 showed weak expression in 25 （83.3%） cases. Conclu- sion MUM-1 is a highly sensitive marker for Reed-Steinberg cells,which is helpful to diagno- sis of classical Hodgkin lymphoma and has a high negative predictive value for excluding the classical Hodgkin lymphoma.

关 键 词：经典型霍奇金淋巴瘤 MUM-1 免疫组织化学 

分 类 号：R733[医药卫生—肿瘤]