手术治疗对早期小细胞肺癌的疗效观察  

The effect of surgical treatment for small cell lung cancer in early stage

作　　者：李毅[1] 张临友[1] 张永强[2] 李仕逵[2] 李永超[1] 王淑霞[1] 牛楠[1] 李少鹏[1] 

机构地区：[1]哈尔滨医科大学附属第二医院胸外科,黑龙江哈尔滨150081 [2]大庆油田总医院胸外科,黑龙江大庆163000

出　　处：《哈尔滨医科大学学报》2013年第2期181-183,共3页Journal of Harbin Medical University

摘　　要：目的分析150例小细胞肺癌患者外科治疗的预后,评估外科手术在早期小细胞肺癌治疗中的作用及价值。方法 65例小细胞肺癌患者行肺叶切除术和化、放疗(VP方案/钴-60放疗),85例患者行单纯化、放疗(VP方案/钴-60放疗),按照2007年肺癌分期的标准进行分期。结果相对于单纯放、化疗的患者1、3年存活率分别为73%、31%,65例小细胞肺癌患者中,Ⅰ期患者28例,1年及3年生存率分别为100%和82%,Ⅱ期患者37例,1年及3年生存率分别为89%和51%,手术切除辅以术后化、放疗患者的生存期明显延长(P<0.05)。结论对早期的小细胞肺癌患者,手术辅以术后化、放疗方法要优于单纯化、放疗。Objective To analyse the outcome of 150 patients with small cell lung cancer （SCLC） and to evaluate the role of surgery in treatment of SCLC. Methods Sixty-five pa- tients underwent pulmonary lobectomy combined with chemo/radio （VP/Co-60） therapy, and 85 patients with only ehemo/radio therapy （VP/Co-60）. Clinical stages were carried on ac- cording to the new international staging system （2007 System）. Results Compared to the pa- tients with only ehemo/radio（VP/Co-60） therapy （1-year and 3-year survival rate were 73% and 31% ） , in 65 patients of surgery group, l-year and 3-year survival rate were 100% and 82% in 28 patients in stage I , and rats of those were 89% and 51% in 37 patients in stage Ⅱ. The survival time of the patients with pulmonary lobectomy combined with chemo/radio- therapy was significantly prolonged. Conclusion The therapy of surgery treatment combined with chemo/radio（VP/Co-60） therapy is better than chemo/radio（VP/Co-60） only for the pa- tients with SCLC in the early stage.

关 键 词：小细胞肺癌 手术治疗 化疗 放疗 

分 类 号：R734.2[医药卫生—肿瘤]