声脉冲辐射力成像评价肝占位患者肝纤维化与病理对照研究  被引量:6

Acoustic Radiation Force Impulse Imaging in Space-occupying Liver Lesions: Correlation with Pathology

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作  者:闫荟同[1] 唐文博[1] 宋欣[2] 邓晋芳[2] 罗渝昆[1] 唐杰[1] 

机构地区:[1]解放军总医院超声科,北京100853 [2]解放军总医院病理科,北京100853

出  处:《中国医学影像学杂志》2013年第5期367-369,373,共4页Chinese Journal of Medical Imaging

基  金:国家自然科学基金项目(81271588)

摘  要:目的探讨声脉冲辐射力成像(ARFI)所测肝占位患者肝实质硬度(LS)值与病理的相关性,评估ARFI技术诊断肝纤维化的价值。资料与方法应用ARFI技术检测73例肝占位患者的LS值,对患者术后肿瘤周围肝组织进行病理Metavir分期,分析LS值与各病理分期的相关性。结果 LS值为0.98~3.96m/s,平均(1.78±0.53)m/s,与肝纤维化病理Metavir分期之间呈显著正相关(r=0.701,P〈0.001)。肝纤维化病理分期F0~F4期LS值分别为(1.19±0.12)m/s、(1.25±0.13)m/s、(1.50±0.18)m/s、(1.66±0.19)m/s、(2.13±0.54)m/s,组间差异有统计学意义(H=62.92,P〈0.001);F0期与F1期LS值差异无统计学意义(P〉0.05),其余各期两两比较,差异均有统计学意义(P〈0.05、P〈0.01)。结论 ARFI技术能够有效评价肝纤维化程度,与肝组织活检在肝纤维化评估中的作用相当。Purpose To investigate the correlation of liver stiffness (LS) determined by acoustic radiation force impulse (ARFI) imaging with pathology, and to evaluate the signification of ARFI in diagnosing liver fibrosis. Materials and Methods Seventy-three patients with space-occupying liver lesions were examined by ARFI to determine the LS value. Metavir staging of peritumoral liver parenchyma after resection was correlated with LS. Results The LS values ranged from 0.98 m/s to 3.96 m/s with an average of (1.78±0.53) m/s, it showed positive correlation with Metavir staging (r=0.701, P<0.001). The LS was (1.19±0.12) m/s, (1.25±0.13) m/s, (1.50±0.18) m/s, (1.66±0.19) m/s and (2.13±0.54) m/s for stage F0 to F4 fibrosis, respectively (H=62.92, P<0.001). There was no signification difference between F0 and F1 fibrosis (P>0.05), but there were statistical differences between the other two stages (P<0.05, P<0.01). Conclusion ARFI technique accurately evaluates liver fibrosis and correlates well with liver biopsy.

关 键 词:肝疾病 超声检查 多普勒 彩色 弹性成像技术 声脉冲辐射力成像 肝硬化 病理学 临床 

分 类 号:R735.7[医药卫生—肿瘤] R730.41[医药卫生—临床医学]

 

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