Pin1基因-842位点多态性与阿尔茨海默病发病相关性的Meta分析  

A Meta-analysis of Pin1 gene polymorphism at -842 loci and the risk of having Alzheimer's disease

作　　者：邱金华[1,2] 黄国良[1] 何志巍[1] 

机构地区：[1]广东医学院中美肿瘤研究所,广东东莞523808 [2]惠州市第一人民医院神经内科,广东惠州516000

出　　处：《热带医学杂志》2013年第5期616-619,共4页Journal of Tropical Medicine

基　　金：广东省医学科研基金(B2011232)

摘　　要：目的综合评价Pin1基因-842位点多态性与阿尔茨海默病易感性的关系。方法检索CNKI和Medline数据库,获得有关Pin1基因-842位点多态性与阿尔茨海默病易感性关系的研究结果,并在不同对比模型中进行Meta分析。结果本次Meta分析共纳入6项研究,累计病例1750例,对照者1626名。基因变异在CCVSGG模型中,OR值为1.42(95%CI:0.71～2.84),P值为0.32;基因变异在GCVSGG模型中,OR值为1.05(95%CI:0.88～1.26),P值为0.58;在CC+GCVSGG模型中,OR值为1.24(95%CI:0.86～1.79),P值为0.25。结论尚无足够证据证明Pin1基因-842位点多态性与阿尔茨海默病易感性有关。Objective To evaluate the relationship between Pinl gene polymorphism at -842 loci and the risk of having Alzheimer＇s disease. Methods Information obtained from CNKI and Medline was used in the analysis. Results Six case-control studies with 1 750 cases and 1 626 controls were analyzed in this Meta-analysis. In the CC VS GG contrast model, the pooled OR value was 1.42 （95%CI： 0.71-2.84）, and the P value was 0.32. In the GC vs GG contrast model, the pooled OR value was 1.05 （95%CI： 0.88-1.26）, and the P value was 0.58. In the CC＋GC vs GG contrast model, the pooled OR value was 1.24 （95%CI： 0.86-1.79）, and the P value was 0.25. Conclusion Genetic polymorphism of Pinl gene at -842 loci might not contribute to the susceptibility of Alzheimer＇s disease.

关 键 词：阿尔茨海默病 PIN1 多态性 META分析 

分 类 号：R74[医药卫生—神经病学与精神病学]