血管成形与脐带干细胞移植治疗糖尿病足:3个月血管造影评价(英文)  

Human umbilical cord mesenchymal stem cell transplantation combined with angioplasty for diabetic foot: 3 months angiographic evaluation

作　　者：秦汉林[1] 贺克武[1] 高斌[1] 季亚莉[2] 黄永翠[2] 王胜琴[2] 胡国平[2] 周学勇[2] 

机构地区：[1]合肥市第一人民医院介入科,安徽省合肥市236001 [2]安徽省血液中心,安徽省合肥市236001

出　　处：《中国组织工程研究》2013年第14期2544-2551,共8页Chinese Journal of Tissue Engineering Research

基　　金：Annual Planning Project of Anhui Science and Technology Department,No.09020303043~~

摘　　要：背景:目前对糖尿病继发肢体动脉闭塞尚无有效的药物治疗,最终多导致截肢,预后很差。目的:以血管成形联合人脐带间充质干细胞移植治疗糖尿病足,3个月后行血管造影评价效果。方法:确诊症状严重伴有下肢动脉不同程度病变的Fontain Ⅳ期糖尿病足40例52条患肢,对照组12例患者18条患肢给予单纯介入治疗,实验组28例34条患肢给予介入联合人脐带间充质干细胞经导管灌注及溃疡周围注射治疗,随访3个月。结果与结论:治疗后患肢冷感、疼痛、麻木等临床症状持续改善,患肢皮温、踝肱指数值及跛行距离均增加。治疗3个月后复查造影,新生血管增多,溃疡逐渐愈合或缩小,输注前后未出现严重并发症和不良反应。说明采用血管成形联合人脐带间充质干细胞移植治疗糖尿病足,方法可行、安全,近期疗效满意。BACKGROUND： At present, there is no effective drug for the treatment of diabetic arteniosclerosis obliterons, and most of the patients have to receive amputation, and have poor prognosis. OBJECTIVE： To treat the diabetic foot with human umbilical cord mesenchymal stem cells transplantation combined with angioplasty, and to perform the angiographic evaluation at 3 months after operation. METHODS： Forty cases （52 limbs） diagnosed with severe symptoms of Fontain IV diabetic foot accompanied with varying degrees of lower extremity arterial disease were included. The 12 cases （18 limbs） in the control group received simple interventional treatment, and 28 cases （34 limbs） in the experimental group were given human umbilical cord mesenchymal stem cells endovascular infusion and injection around the ulcer. Then all the patients were followed-up for 3 months. RESULTS AND CONCLUSION： Local cool-feeling, pain and numbness after treatment were improved continuously in a certain extent; skin temperature, ankle-brachial pressure index and claudication distance were improved persistently. Re-examination angiography at 3 months after treatment showed that the neovessels were increased significantly and the ulcer was healed or decreased gradually. No serious complications and adverse reactions were observed before and after infusion. The results indicate that human umbilical cord mesenchymal stern cell transplantation combined with angioplasty is a safe, effective and satisfactory method for severe diabetic foot.

关 键 词：干细胞 干细胞移植 2型糖尿病 外周血管病变 糖尿病足 溃疡 介入 血管成形 人脐带间充质干细胞 移植 疗效 并发症 省级基金 干细胞图片文章 

分 类 号：R394.2[医药卫生—医学遗传学]