小剂量他克莫司治疗难治性全身型重症肌无力的初步评价  

Preliminary Evaluation of Low-dose Tacrolimus Treatment in Refractory Generalized Myasthenia Gravis

作　　者：林婧[1] 李荣[1] 张旻[1] 李悦[1] 陈博[1] 卜碧涛[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院神经内科,武汉430030

出　　处：《神经损伤与功能重建》2013年第3期181-184,共4页Neural Injury and Functional Reconstruction

摘　　要：目的:探讨小剂量他克莫司用于难治性全身型重症肌无力的疗效。方法:选择12例临床资料完整的难治性全身型重症肌无力患者,采用小剂量他克莫司进行治疗,分析患者的一般情况、Oosterhuis记分、MG-ADL评分、药物用量等。结果:9例坚持用药的患者Oosterhuis记分均明显减少;5例现生活自理,1例因股骨头坏死致行动困难,但肌力明显改善;5例住院次数减少,用药后8例患者使用激素量减低,1例为小剂量长期维持。结论:小剂量他克莫司治疗难治性全身型重症肌无力,可改善日常生活质量,减少激素用量。Objective： To evaluate the efficacy oflow-dose tacrolimus treatment on patients with refractory generalized myasthenia gravis （MG）. Methods： Twelve cases of refractory generalized MG were treated with low dose of FK-506. The clinical manifestation, Oosterhuis score, MG-ADL score and drugs usage were evaluated. Results： Oosterhuis scores was improved in 9 cases with regular therapy of FK-506. Five cases could take care of themselves in daily life. Only 1 case was confined to bed because of femoral bone head necrosis, but the muscle strength improved significantly. The frequency of hospitalization was reduced in 5 cases. The doses ofprednisolone were also reduced in 8 cases, and 1 case with long-term maintenance in low dose. Conclusion：Low-dose tacrolimus was effective and safe in the treatment of refractory generalized MG.

关 键 词：重症肌无力 他克莫司 激素 

分 类 号：R741[医药卫生—神经病学与精神病学] R746.1[医药卫生—临床医学]