脑血管病患者胃动素的临床研究  

A clinical study on levels of motilin in plasma in patients with cerebrovascular disease

作　　者：李义召[1] 孙琳[2] 刘爱芬[1] 张东君[1] 刘建伟[1] 刘言训[3] 

机构地区：[1]山东医科大学附属医院,250012 [2]山东医科大学附属第二医院 [3]山东医科大学

出　　处：《卒中与神经疾病》2000年第2期89-92,共4页Stroke and Nervous Diseases

摘　　要：目的 :观察脑出血 (CH)、脑梗死 (CI)、蛛网膜下腔出血 (SAH)患者胃动素 (MTL)水平的动态变化及其临床意义。方法 :选择脑血管病 (CVD)患者 1 38例。用放免法检测血浆 MTL浓度。结果 :CVD各组 MTL水平显著高于对照组 ,发病 2 4 h内即升高 ;CI组、SAH组 4～ 7d达峰水平 ,CH组 1～ 3d达峰水平 ;8～ 1 5d降低 ,1 5d仍在较高水平 ;随病情严重程度的加重 MTL水平升高 ;高血糖组显著高于正常血糖组。结论 :CI、CH、SAH患者存在 MTL分泌异常 ,各组 CVD MTL动态检测可作为病情严重程度、病灶大小及预后的重要指标 ,提示 MTL参与了Objective:To observe levels of motilin in plasma and its clinical significance in patients with cerebral hemorrhage or cerebral infarction or subarachnoid hemorrhage.Methods: The levels of motilin in plasma were measured by radioimmunoassay in 138 cases of cerebrovascular disease and 28 healthy control subjects. Results: The levels of motilin in plasma in the three groups of cerebrovascular disease were increased more than that in control group. The levels of motilin in plasma in the three groups started to increase significantly during the first day. The levels of motilin in plasma reached the peak in the three groups of cerebrovascular disease on day 1 to 3 or day 4 to 7. They began to decrease from the eighth day. The levels of motilin in the three groups of cerebrovascular disease were higher than that in control group after 15 days. The severer the condition of cerebrovascular diseases , the higher the motilin levels. Conclusion: Motilin plays a major role in pathophysiological and pathogenetic mechanisms of cerebrovascular disease .

关 键 词：脑梗死 脑出血 蛛网膜下腔出血 胃动素 

分 类 号：R743.302[医药卫生—神经病学与精神病学]