射频低温等离子体对抗菌性室温固化PMMA材料中残余MMA浓度的影响  

Effect of radio frequency low temperature plasma treatment on concentration of residual MMA in antibacterial room temperature curing PMMA material

作　　者：杨芸[1] 王晓容[1] 韩凌宇[1] 张赢心[1] 阎通通[1] 刘童斌[1] 申证暄[1] 

机构地区：[1]吉林大学口腔医院口腔修复科,吉林长春130021

出　　处：《吉林大学学报（医学版）》2013年第3期482-487,共6页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅科技发展计划项目资助课题(20090462)

摘　　要：目的:研究添加2%纳米载银无机抗菌剂对室温固化聚甲基丙烯酸甲酯(PMMA)材料中残余单体甲基丙烯酸甲酯(MMA)浓度的影响,观察不同低温等离子体氩气(Ar)和四氟化碳(CF4)处理后残余MMA的浓度变化。方法:采用球磨法将2%纳米载银无机抗菌剂添加到室温固化PMMA材料中制备抗菌试件(抗菌组)和未添加抗菌剂的室温固化PMMA(对照组)。采用Ar和CF42种不同低温等离子体分别对抗菌组和对照组进行表面改性和表面轰击处理,用丙酮分别抽提处理前后固体试件中残留的MMA,用氯仿萃取其在人工唾液中释放的MMA,气相色谱法测定抽提液和萃取液中MMA的浓度。结果:与对照组比较,抗菌组PMMA材料中残余MMA百分含量差异无统计学意义(P>0.05);经低温等离子体处理后得到的材料中MMA的百分含量及释放量明显不同,其中以对照组经CF4低温等离子体表面轰击处理后得到的材料中残余MMA浓度最低;在人工唾液中浸泡2d后MMA的释放量与浸泡1d比较差异有统计学意义(P<0.05),而浸泡时间超过2d,随着时间的延长,材料在人工唾液中MMA的释放量趋于稳定;抗菌组经CF4等离子体表面改性和表面轰击处理后,MMA释放的最大量分别出现在第2天和第4天,均分别高于本组其他时间点MMA的释放量(P<0.05)。结论:添加2%的纳米载银无机抗菌剂对室温固化PMMA材料中残余MMA浓度无显著影响,低温等离子体表面处理技术可显著降低室温固化PMMA材料中残余MMA的浓度及其在唾液中的释放量。Objective To investigate the effect of 2% nano-silver base inorganic antibacterial agent on concentration of residual methylmethacrylate（MMA） of room temperature curing polymethylmethacrylate（PMMA） material and to observe the concentration changes of the residual MMA after treated with low temperature plasma argon（Ar） and tetrafluoromethane（CF4）.Methods 2% nano-silver base inorganic antibacterial agent was added into the room temperature curing PMMA material through ball milling method to make specimen.Both antibacterial room temperature curing PMMA material group（antibacterial group） and conventional room temperature curing PMMA group（control group） were treated with Ar and CF4 plasma surface modification and surface bombardment processing.And then acetone and chloroform were used to extract the residual MMA of the specimens before and after treatment and residual MMA released from the specimens into artificial saliva,separately.Gas chromatography（GC） method was used to determine the concentrations of residual MMA in tiye pumping and extract.Results Compared with control group,the addition of 2% nano-silver base inorganic antibacterial agent did not show statistical significance for the residual MMA concentration in PMMA material in antibacterial group had no significant difference（P0.05）.There were siginficant differences of the concentration and release amount of MMA in the materials after treated with low temperature plasma,and the concentration of the residual MMA in the materials obtained in control group after treatment of CF4 plasma bombardment was the lowest.The content of MMA in the artificial saliva was also quite different in the second day compared with the first day（P0.05）.After 2 d,with the prolongation of time,the amount of MMA released from polymers tended to be stable.In antibacterial group,when the specimens were treated with CF4 plasma surface bombardment and surface modification,the maximum amounts of MMA appeared in the second day and the fourth day,which

关 键 词：低温等离子体 纳米载银无机抗菌剂 室温固化 聚甲基丙烯酸甲酯 残余单体甲基丙烯酸甲酯 

分 类 号：R783.1[医药卫生—口腔医学]