CYP11B2基因多态性与缺血性脑卒中关联性的Meta分析  

Association between CYP11B2 gene polymorphisms and ischemic stroke:a Meta-analysis

作　　者：林慧中[1] 林涛[2] 陈慧[3] 

机构地区：[1]福建医科大学附属协和医院心内科,福建福州350004 [2]福建医科大学公共卫生学院流行病与卫生统计学系,福建福州350004 [3]福建省立医院心内科,福建福州350003

出　　处：《吉林大学学报（医学版）》2013年第3期578-583,共6页Journal of Jilin University：Medicine Edition

基　　金：福建省自然科学基金重点项目资助课题(C0420003)

摘　　要：目的:对醛固酮合成酶基因CYP11B2的(-344C/T)基因位点多态性与缺血性脑卒中(IS)的关联性进行Meta分析,为IS的治疗提供依据。方法:联合检索1990-2012年中国期刊全文数据库、中国生物医学文献数据库、维普中文期刊数据库、万方数据库、PubMed和Cochrane Collaboration Database电子数据库。采用RevMan 5.0软件对纳入文献进行Meta分析,并进一步进行异质性检验、敏感性分析和偏倚评估。结果:共纳入6篇相关文献。IS组与对照组TT/(TT+CC)合并OR(95%CI)值为1.51(1.06,2.16,P<0.05)。大动脉粥样硬化性脑卒中(LAA)组与对照组TT/(TT+CC)合并OR(95%CI)值为1.85(1.11,3.08,P<0.05);多发腔隙性脑卒中或小动脉闭塞性脑卒中(MLI)组与对照组TT/(TT+CC)合并OR(95%CI)值为2.46(1.21,4.99,P<0.05)。结论:CYP11B2基因TT基因型与IS有关联性,TT基因型与LAA和MLI亦有关联性,提示CYP11B2基因可能为IS的遗传候选基因。Objective To investigate the association between aldosterone synthase CYP11B2（-344C/T） gene polymorphism and ischemic stroke（IS） by Meta-analysis and to provide evidence for the treatment of IS.Methods Case-control studies on the association between CYP11B2 gene polymorphism and IS from 1990 to 2012 were collected from China national knowledge internet,Chinese biological medicine disk,Vip fulltext database,Wanfang fulltext database,PubMed and Cochrane Collaboration Database.Meta-analysis was carried out after strict screening.Heterogeneity test,sensitivity analysis and publication bias assessment were also performed.Results A total of 6 studies were included.In IS group,the pooled OR（95% CI） of TT /（TT ＋ CC） genotype was 1.51（1.06,2.16,P0.05）.In large artery atherosclerotic stroke LAA group,the pooled OR（95% CI） of TT/（TT ＋ CC） genotype was 1.85（1.11,3.08,P0.05）.In multiple lacunar stroke（MLI） group,the pooled OR（95% CI） of TT/（TT ＋ CC） genotype was 2.46（1.21,4.99,P0.05）.Conclusion The TT genotype of CYP11B2 gene is associated with IS,and TT genotype is also associated with LAA and MLI,which indicats that CYP11B2 gene is possiblely the candidate gene of IS.

关 键 词：醛固酮合成酶 缺血性脑卒中 基因多态性 META分析 

分 类 号：R734.3[医药卫生—肿瘤]