子宫动脉化疗栓塞术联合放疗治疗中晚期宫颈癌的临床研究  

Clinical research of uterine artery chemoembolization combined with radiotherapy for intermediate and advanced cervical cancer

作　　者：王晓燕[1] 陈建华[1] 刘永利[1] 李宁[1] 张花梅[1] 李静[1] 

机构地区：[1]山东省滨州市中心医院结防院妇产科,251700

出　　处：《中国医师进修杂志》2013年第15期34-37,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨子宫动脉化疗栓塞术联合放疗治疗中晚期宫颈癌的临床效果。方法将80例中晚期宫颈癌患者按照随机数字表法分为治疗组和对照组，每组40例。治疗组给予子宫动脉化疗栓塞术＋放疗治疗，对照组给予静脉化疗＋放疗治疗。观察两组近期疗效、远期生存率及不良反应情况。结果治疗组完全缓解率和客观有效率均优于对照组[72．5％（29／40）比50．0％（20／40）、95．O％（38／40）比80．0％（32／40），P〈0．05]。两组患者的1、2、3年生存率比较差异无统计学意义（P〉O．05）。治疗组白细胞下降、贫血、血小板下降及恶心呕吐的发生率明显低于对照组[32．5％（13／40）比67．5％（27／40）、30．0％（12／40）比75．0％（30／40）、7．5％（3／40）比17．5％（7／40）、37．5％（15／40）比70．O％（28／40），P〈0．05]；两组放射性直肠炎、放射性膀胱炎的发生率比较差异无统计学意义（P〉0．05）。结论子宫动脉化疗栓塞术联合放疗可提高中晚期宫颈癌的近期疗效，不良反应较少。Objective To investigate the clinical efficacy of uterine artery chemoembolization combined with radiotherapy in the treatment of intermediate and advanced cervical cancer. Methods Eighty patients with intermediate and advanced cervical cancer were randomly divided into treatment group and control group by random digits table with 40 patients each. The patients in treatment group were received uterine artery chemoembolization and radiotherapy. The patients in control group were received radiotherapy and intravenous chemotherapy. The short-term efficacy, survival and untoward reaction were observed in 2 groups. Results The complete remission rate and objective response rate in treatment group were significantly higher than those in control group [ 72.5% （29/40） vs. 50.0%（20/40）, 95.0% （38/40） vs. 80.0% （32/40）,P 〈 0.05 ]. There was no significant difference in survival rate of 1,2 and 3-year between the 2 groups （P 〉 0.05）. The incidence rates of leukopenia,anemia,thrombocytopenia,nausea and vomiting in treatment group were significantly lower than those in control group [ 32.5% （13/40） vs. 67.5% （27/40）, 30.0%（12/40） vs. 75.0%（30/40）,7.5%（3/40） vs. 17.5%（7/40）,37.5%（15/40） vs. 70.0%（28/40）,P 〈 0.05 ]. There were no significant difference in the incidence rates of radiation cystitis and radiation proctitis between the 2 groups （P 〉 0.05）. Conclusion Uterine artery chemoembolization combined with radiotherapy for intermediate and advanced cervical cancer can improve short-term efficacy and with less side effects.

关 键 词：宫颈肿瘤 放射疗法 计算机辅助 栓塞 治疗性 

分 类 号：R737.33[医药卫生—肿瘤]