亲肿瘤显像剂^(99)Tc^m(V)-DMSA显像对^(153)Sm-EDTMP治疗骨转移癌的疗效评价  

The Evaluation of ^(153)Sm-EDTMP Therapy of Disseminated Skeletal Metastases Using Tumor Seeking Agent ^(99)Tc^m (V)-DMSA

作　　者：李林[1] 邓候富[1] 谭天秩[1] 匡安仁[1] 

机构地区：[1]华西医科大学附属一院核医学科,四川成都610041

出　　处：《同位素》2000年第1期41-44,共4页Journal of Isotopes

基　　金：国家自然科学基金资助课题!(2 99710 2 7)

摘　　要：使用亲肿瘤显像剂 99Tcm ( ) - DMSA,对 16例经 153 Sm- EDTMP治疗 2～ 8个疗程后的骨转移癌患者进行随访显像研究。结果表明 ,中轴骨转移灶的消失率为 4 8.1% ,四肢骨转移灶消失率为4 1.9% ,总的骨转移灶消失率为 4 5.8%。99Tcm ( ) - DMSA具有亲肿瘤特性和亲骨性 ,对于 153 Sm-EDTMP治疗骨转移癌疗效的随访 ,具有理论上的可信性和客观性 ;对于 153 Sm- EDTMP治疗方案的选择、剂量的确定及病人预后的判断具有重要的临床价值。Using tumor- seeking agent 99Tcm ( ) - DMSA,follow- up imaging studies are performed on 1 6 cases of disseminated metastases who received 2～ 8times of1 53Sm- EDTMP radiation therapy.The results indicate that the disappearance rate of axial skeletal lesions and long bone lesions are48.1 % and41 .9% respectively,the total disappearance rate of skeletal lesions is 45 .8% . Since99Tcm( ) - DMSA has a affinity to tumor and bone tissue,it is notonly theoretically reliable and objective in judging the patients response to1 53Sm- EDTMP,but also clinically important in selecting therapeutic methodology,determining of dosage and assessing of patient's prognosis.

关 键 词：Tc99(V)-DMSA Sm153-EDTMP 治疗 骨转移癌 

分 类 号：R738.104[医药卫生—肿瘤] R730.44[医药卫生—临床医学]