源于果蔬的黄酮类化合物及其抗肿瘤作用靶点研究进展  

Research Advance in Flavonoids Derived from Fruits and Vegetables and Corresponding Molecular Targets of Anticancer

作　　者：任虹[1] 张乃元[2] 田文静[1] 张瑞[1] 胡仁杰[1] 

机构地区：[1]北京工商大学食品学院食品添加剂与配料北京高校工程研究中心北京市食品风味化学重点实验室,北京100048 [2]武汉大学公共卫生学院,湖北武汉430071

出　　处：《食品科学》2013年第11期321-326,共6页Food Science

基　　金：国家"863"计划项目(2007AA09Z411)

摘　　要：黄酮类化合物(flavonoids)广泛存在于各种水果、蔬菜中,具有种类繁多、结构复杂、药理活性强、毒副作用低的特点,富含黄酮类化合物的果蔬饮食可有效降低恶性肿瘤的患病率,对于恶性肿瘤的预防和治疗具有广泛意义。本文按化合物结构综述源于果蔬的黄酮类化合物及其抗肿瘤作用靶点的研究进展,为进一步开拓其食疗价值提供科学依据。Flavonoids are existed widely in various fruits and vegetables with the characteristics of large amount, complex structure, obvious pharmacological activity and low toxicity. A diet rich in flavonoids can be associated with the reduced risk for cancers, which has important significance on prevention and treatment of malignant tumors. In this paper, the studies on flavonoids derived from fi＇uits and vegetables as well as their anticancer activity and corresponding molecular targets in terms of their chemical structures are summarized, which will provide a scientific basis for further developing their therapeutic value of diets.

关 键 词：果蔬 黄酮类化合物 抗肿瘤活性 作用靶点 

分 类 号：O629.9[理学—有机化学]