PAR-2、VEGF和CD34在胃癌组织中的表达及其临床意义  

Expression and significance of protease-activated receptor-2, VEGF and CD34 in gastric cancer tissue

作　　者：张成[1] 高广荣[1] 李达[1] 吕晨光[1] 蒋会勇[1] 李瑾[1] 张雪峰[1] 

机构地区：[1]沈阳军区总医院普通外科,110840

出　　处：《实用医学杂志》2013年第11期1773-1776,共4页The Journal of Practical Medicine

基　　金：中国博士后科学基金资助项目(编号:20090451564)

摘　　要：目的:探讨PAR-2、VEGF和CD34在胃癌组织中的表达及其临床病理意义。方法 :应用免疫组织化学方法检测80例胃癌组织中PAR-2、VEGF和CD34的表达,并分析PAR-2与VEGF、CD34表达及临床病理特征的关系。结果:80例胃癌组织标本中42例(52.5%)PAR-2表达阳性,52例(65.0%)VEGF表达阳性,51例(63.8%)CD34表达阳性;PAR-2蛋白主要表达在肿瘤细胞的胞膜和胞浆中,而VEGF蛋白主要表达于胞浆中;PAR-2的表达与肿瘤浸润深度、远隔转移和病理分期呈正相关;PAR-2的表达与VEGF和CD34的表达呈正相关。结论:PAR-2可能在胃癌组织新生血管形成中发挥了重要作用。Objective To investigate the expression and clinicopathological significance of PAR-2, VEGF and CD34 in gastric carcinoma tissues. Methods PAR-2, VEGF and CD34 were detected by immunohistochemistry, and the correlation of PAR-2 expression with VEGF and CD34 expressions and clinical pathologic factors was analyzed. Results Immunohistochemistry results showed that the positive expressions of PAR-2 , CD34 and VEGF in gastric carcinoma tissues were 52.5%, 63.8% and 65.0%. PAR-2 expression in the cell membrane and cytoplasm of tumor ceils, whereas VEGF mainly in the cytoplasm. Linear correlation analysis showed significant inverse relationship between expression of PAR-2 and clinical stage, depth of infiltration and distant metastasis, and positive correlation between expression of PAR-2 and VEGF, CD34. Conclusion The overexpression of PAR-2 is related with the neovascularization in gastric carcinoma tissues.

关 键 词：胃肿瘤 蛋白酶激活受体-2 血管内皮细胞生长因子 CD34 

分 类 号：R735.2[医药卫生—肿瘤]