老年急性脑梗死患者血浆氧化低密度脂蛋白与颈动脉粥样硬化斑块的关系  

Relationship between plasma oxidized low density lipoprotein and carotid atherosclerotic plaque in elderly patients with acute cerebral infarction

作　　者：胡方方[1] 徐书雯[1] 谢静芳[1] 陈伟平[1] 向绍通[1] 

机构地区：[1]广东省人民医院神经内科(广东省医学科学院),广东省老年医学研究所,广东省神经科学研究所,广州市510080

出　　处：《实用医学杂志》2013年第11期1788-1790,共3页The Journal of Practical Medicine

基　　金：2012年广东省第四批科技计划(自筹资金)资助项目(编号:20120404);广东省中医药管理局课题基金支助项目(编号:2007177)

摘　　要：目的:探讨老年急性脑梗死(acute cerebral infarction,ACI)患者血浆氧化低密度脂蛋白(oxidizedlow density lipoprotein,OXLDL)与颈动脉粥样硬化斑块的关系。方法 :60例ACI患者按颈动脉超声检测结果分为颈动脉无斑块组(5例)和斑块组(55例),后者再分为不稳定斑块亚组(40例)和稳定斑块亚组(15例);对所有患者均行OXLDL检测,比较各组间的血浆OXLDL水平。结果 :血浆OXLDL水平颈动脉斑块组(0.76±0.35)mg/L显著高于无斑块组(0.42±0.38)mg/L,不稳定斑块亚组(0.81±0.34)mg/L显著高于稳定斑块亚组(0.61±0.36)mg/L(均P<0.05)。结论:血浆OXLDL水平可间接反映颈动脉斑块的稳定性,血浆OXLDL水平与颈动脉粥样硬化斑块两者联合检测可更好地预测老年ACI的发生。Objective To study the relationship between plasma oxidized low density lipoprotein （OXLDL） and carotid atherosclerotic plaque in elderly patients with acute cerebral infarction （ACI）. Methods Sixty ACI patients were divided into carotid artery no-plaque group （5 cases） and carotid artery plaque group （55 cases） while the latter included unsteady plaque subgroup （40 cases ） and steady plaque subgroup （ 15 cases）, according to the results of carotid artery ultrasonic examination. The levels of OXLDL were detected in all the patients. The levels of OXLDL were compared among the groups. Results The levels of OXLDL in carotid artery plaque group （0.76± 0.35）mg/L was significantly higher than those in no-plaque group （0.42 ± 0.38）mg/L, and in the unsteady plaque subgroup （0.81 ±0.34）mg/L significantly higher than which in steady plaque subgroup （0.61± 0.36）mg/L （both P 〈 0.05）. Conclusion The levels of OXLDL could indirectly reflect the unsteady of carotid artery plaque. Both of the levels of OXLDL and carotid artery plaque could predict the occurrence of ACI better.

关 键 词：脑梗死 颈动脉粥样硬化斑块 氧化低密度脂蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学]