原发性舍格伦综合征患者唇腺组织中IFN-α的表达  

Expression of interferon-alpha in primary sjogren's syndrome

作　　者：王彦焱[1] 凌彬[2] 罗莉[1] 龚忠诚[2] 赵春梅[1] 吴江[3] 

机构地区：[1]新疆医科大学第一附属医院风湿科,新疆乌鲁木齐830054 [2]新疆医科大学第一附属医院颌面肿瘤外科,新疆乌鲁木齐830054 [3]新疆医科大学基础医学院,新疆乌鲁木齐830011

出　　处：《临床和实验医学杂志》2013年第11期817-818,821,共3页Journal of Clinical and Experimental Medicine

基　　金：新疆医科大学第一附属医院青年基金(2010GXB07);国家自然科学基金项目(10802054;11262020);新疆维吾尔自治区自然科学基金项目(201233146-9)资助

摘　　要：目的检测原发性舍格伦综合征(pSS)患者唇腺中干扰素(IFN)-α的表达水平,探讨其在pSS发病机制产生的作用。方法对41例pSS患者和32例非pSS患者的唇腺组织进行IFN-α免疫组化染色,比较分析其在两组之间的差异。结果对IFN-α检测后发现,41例pSS患者中,32例表达阳性,阳性率78.05%;32例非pSS患者中4例表达阳性,阳性率2.5%。两组之间差异有显著性(P<0.05)。结论 IFN-α在pSS患者唇腺组织中存在异常表达,可能与其发病机制相关。Objective To investigate the interferon-α levels in the labial glands of patients with primary Sjogren＇s syndrome（pSS）,and explore the etiopathogenesis between pSS and interferon-α.Methods Immunohistochemistry was used to examine interferon-αpositive cells in labial glands in 41 patients with pSS and 32 patients with non-pSS.SAS 6.12 software package was used for student＇s t test.Results The positive expressions of interferon-α cells in the labial glands were found in 22 of 41 patients（78.05%） with pSS.The positive expressions of interferon-α cells in the labial glands were detected in 4 of 32 patients（2.5%） with non-pSS.There was significant difference between pSS and non-pSS.Conclusion The study revealed that the expression of interferon-α in the labial glands of patients with pSS were abnormal.It may be related with pathogenesis of primary Sjogren＇s syndrome.

关 键 词：原发性舍格伦综合征 唇腺 干扰素-Α 免疫组织化学 

分 类 号：R781.77[医药卫生—口腔医学]