淋巴瘤相关血栓的临床分析  

Clinical features of lymphoma-related thrombosis

作　　者：刘鹏飞[1] 李亚妮[1] 李兰芳[1] 刘贤明[1] 王华庆[1] 

机构地区：[1]天津医科大学附属肿瘤医院淋巴瘤科,中美淋巴血液肿瘤诊治中心,天津市肿瘤防治重点实验室,天津市300060

出　　处：《中国肿瘤临床》2013年第10期596-599,共4页Chinese Journal of Clinical Oncology

基　　金：天津市卫生局科技基金项目(编号:2012KZ063)资助~~

摘　　要：目的:本研究主要分析和总结淋巴瘤(Malignant lymphoma,ML)患者发生静脉血栓栓塞(venous thrombolism,VTE)的临床特点,为预防和治疗ML相关VTE提供有效依据。方法:回顾性分析天津医科大学附属肿瘤医院2000年1月至2009年12月收治的经病理证实的4 256例ML患者的临床资料,病理诊断依据WHO的造血与淋巴组织肿瘤分类标准(第4版)。结果:ML相关VTE的发病率为7.1%,NHL患者并发VTE的发病率为5.7%,HL患者并发VTE的发病率为1.3%;16.4%的患者在治疗前形成血栓,75.8%的患者血栓发生在化疗的前3个周期。上肢和颈部静脉血栓事件共146次(48.4%),下肢静脉血栓事件共89次(29.5%)。结论:ML相关VTE的发病率较高,上肢和颈部静脉血栓发生率较下肢更常见,在化疗的前3个周期中血栓的发生率最高。Objective： This study aimed to investigate the clinical features of malignant lymphoma （ML） combined with venous thrombolism （VTE） and to provide primary information for its prevention. Methods： Clinical data of 4 256 patients with ML treated from January 2000 to December 2009 were retrospectively reviewed. All patient pathologies were confirmed according to the World Health Organization classification of hematopoietic and lymphoid tissue tumor standard （fourth edition）. Results： The incidence rate of ML patients with VTE was 7.1%. The incidence rates ofVTE of NHL and HL were 5.7% and 1.3%, respectively. Up to 16.4% patients developed thrombosis before chemotherapy, whereas 75.8% patients had thrombosis after chemotherapy, especially on the first three cy- cles. Upper limb and neck vein thromboembolic incidents occurred 146 times （48.4%） and lower limb thromboembolic events occurred 89 times （29.5%）. Conclusions： ML patients with VTE have higher incidence of upper limb and neck venous thrombosis than lower limb. The highest incidence of ML-related VTE incidents occurs in the first three cycles of chemotherapy.

关 键 词：淋巴瘤 静脉血栓栓塞 临床特征 

分 类 号：R733.1[医药卫生—肿瘤]