^18F-FDGPET／CT全身显像对乳腺癌复发和转移诊断价值分析  

Diagnosis of recurrence and metastasis in post-treatment breast cancer patients using ^(18)F-FDG PET/CT imaging

作　　者：王圣芳[1] 胡旭东[2] 王小玥[1] 杨国仁[3] 马莉[3] 左文述[1] 

机构地区：[1]山东省肿瘤医院外科,山东济南250117 [2]山东省肿瘤医院放疗科,山东济南250117 [3]山东省肿瘤医院PET/CT中心,山东济南250117

出　　处：《中华肿瘤防治杂志》2013年第12期945-948,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨18F-FDG PET/CT全身显像对治疗后乳腺癌复发和转移的诊断价值。方法:回顾性分析山东省肿瘤医院2004-12-01-2009-12-31行18F-FDG PET/CT显像检查的乳腺癌患者142例,统计18F-FDG PET/CT显像诊断的灵敏度、特异性和准确性,并与增强CT及全身骨扫描进行对比。结果:18F-FDG PET/CT和增强CT对乳腺癌复发和转移的灵敏度分别为85.5%(71/83)和77.1%(64/83),特异性分别为88.1%(52/59)和84.7%(50/59),准确性分别为86.6%(123/142)和80.3%(114/142)。18F-FDG PET/CT诊断淋巴结转移的阳性率为89.5%(34/38),高于增强CT的73.7%(28/38),P=0.031;对于局部复发、肺转移、肝转移和脑转移的诊断,18F-FDG PET/CT和增强CT差异无统计学意义;对于骨转移的诊断,18F-FDG PET/CT的灵敏度为70.0%,全身骨扫描为90.0%,两者的特异性分别为100.0%和58.3%。结论:18F-FDG PET/CT显像对治疗后乳腺癌复发和转移诊断具有较高的灵敏度和特异性,但对于不同部位转移灶的诊断应合理选择检查方法。OBJECTIVE： To study the value of 18F-FDG PET/CT imaging detecting recurrence and metastasis in post-treatment breast cancer patients. METHODS： Retrospective analysis of data of 142 patients who underwent 18 F-FDG PET/CT from December 2004 to December 2009 in our hospital. 18F-FDG PET/CT imaging were studied in diagnostic sensitivity, specificity and accuracy according to the different parts of metastasis, and was compared with enhanced CT and whole body bone scan. RESULTS： The diagnostic sensitivity, specificity and accuracy of 18F-FDG PET/CT were better than that in enhanced CT,85. 5% （71/83） vs 77.1%（64/83）,88. 1% （52/59） vs 84.7%（50/59）,86.6% （123/142） vs 80.3%（114/142）. For lymph node metastasis,18 F-FDG PET/CT diagnostic accuracy was 89.5% （34/38）, which was higher than that of enhancement CT 73.7 % （28/38）, P = 0.031. To detect local recurrence, lung metastasis, liver metasta- sis and brain metastasis,there was no statistical difference between the two methods. For the diagnosis of bone metasta- ses, the sensitivity of 18 F-FDG PET/CT were lower thafi whole body bone scan （70.0% vs 90.0%）, and the specificity was higher than that in the latter （100.0% vs 58.3%）. CONCLUSIONS： The 18F-FDG PET/CT imaging has good sensi- tivity and specificity for detecting recurrence and metastasis in post-treatment breast cancer patients. It should be selected as an appropriated imaging methods for different metastasis site.

关 键 词：乳腺肿瘤 PET CT 增强CT 全身骨扫描 复发 转移 

分 类 号：R737.9[医药卫生—肿瘤]