已酮可可碱与沙立度胺联合治疗复发性口疮的疗效评价  

Treatment of recurrent aphthous ulcers with pentoxifylline combined with thalidomide

作　　者：姜军松[1] 陈建中[1] 杨志刚[2] 马景虎[2] 范学东[2] 吕兴标 

机构地区：[1]湖州市解放军98医院,313000 [2]北京市军事医学科学院

出　　处：《实用口腔医学杂志》2000年第3期181-183,共3页Journal of Practical Stomatology

摘　　要：目的 :为确定已酮可可碱与沙立度胺联合治疗复发性口疮的有效性和安全性。方法 :采用双盲法随机对照临床试验 ,已酮可可碱 ( PTX)与沙立度胺 ( TL D)联合治疗的复发性口疮 ( RAU)患者 ,每日口服 PTX40 0 mg TL D10 0 mg,疗程 4周 ,疗程中临床评估溃疡状况及药物副作用各 3次 ,随访 12个月。结果 :联合治疗组 6 7%的患者取得完全缓解 ,疼痛明显改善 ,进食能力加强 ;而对照组只有 6 %的患者获得完全缓解 ( P<0 .0 1)。联合治疗的主要副作用为嗜睡和皮疹。结论 :PTX与 TL砄bjective:To detemine the efficacy and safety of pentoxifylline combined with thalidomide in the treatment of recurrent aphthous ulcers.Methods:A doubleblind,randomized,placebocontrolled study of pentoxifylline (PTX) combined with thalidomide (TLD) as a therapy for the patients with recurrent aphthous ulcers was performed.The patients were given a fourweek course of either 400 mg PTX combined with 100 mg of TLD or placebo orally per day.The effects and side effects were investigalod.Results:Complete healing was observed in 22 of 33 patients (67% treated with PTX and TLD in four weeks,while in only 2 of 33 patients (6%;P<0.01) with placebo.Pain and the difficulty of eating were diminished by PTX plus TLP treatment.The adverse effects of the combination were somnolence and rash.Conclusions:PTX combined with TLD is effective in the treatment of recurrent aphthous ulcers.

关 键 词：已酮可可碱 沙立度胺 复发性口疮 药物疗法 

分 类 号：R781.59[医药卫生—口腔医学]