Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1  

作　　者：Hongmei Tang Rui Pan Wenli Fang Yanyan Xing Dexi Chen Xiaobao Chen Yuanyuan Yu Junbing Wang Zheng Gong Guoyin Xiong Jun Dong 

机构地区：[1]Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University [2]Institute of Brain Research, Medical College of Jinan University [3]Joint Laboratory for Brain Function and Health of Jinan University and the University of Hong Kong [4]Department of Orthopedics, First Affiliated Hospital, Medical College of Jinan University [5]STD/AIDS Research Lab, Beijing Youan Hospital, Capital Medical University

出　　处：《Neural Regeneration Research》2013年第15期1368-1375,共8页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China, No. 81171134;Major State Basic Research Development Program (973 Program), No. 2011CB707500;Science and Technology Foundation of Guangzhou, No. 2010Y1-C291;Science and Technology Foundation of Guangdong Province, No. 2010B030700017;Guangdong Medical Research Funds, No. B2010160;Jinan University-National College Students' Innovative Entrepreneurial Training Programs in 2012, No. 1210559039;the Key Laboratory's Open Fund of Jinan University, No. 51212003;College Students' Extracurricular Scientific Innovation and Entrepreneurial Activity Research Topic of Jinan University Challenge Cup in 2012, No. (2012) 42

摘　　要：Our previous studies have shown that infection with the gp120 V3 loop can cause human immunodeficiency virus-1 associated neurocognitive disorders. Curcumin has been shown to improve these effects to some degree, but the precise mechanisms remain unknown. The present study analyzed the neuroprotective effect and mechanism of curcumin in relation to hippocampal neurons. Results showed that 1 nmol/L gp120 V3 loop suppressed the growth of synapses. After administration of 1 !umol/L curcumin, synaptic growth improved. Curcumin is neuroprotective against gp120 V3 loop-induced neuronal damage by inhibiting the activation of L-type calcium currents, relieving intracellular Ca^2＋ overload, promoting Bcl-2 expression, and inhibiting Bax activation. The effect of curcumin was identical to nimodipine, suggesting that curcumin has the same neuroprotective effects against gp120 V3 loop-induced neuronal damage.Our previous studies have shown that infection with the gp120 V3 loop can cause human immunodeficiency virus-1 associated neurocognitive disorders. Curcumin has been shown to improve these effects to some degree, but the precise mechanisms remain unknown. The present study analyzed the neuroprotective effect and mechanism of curcumin in relation to hippocampal neurons. Results showed that 1 nmol/L gp120 V3 loop suppressed the growth of synapses. After administration of 1 !umol/L curcumin, synaptic growth improved. Curcumin is neuroprotective against gp120 V3 loop-induced neuronal damage by inhibiting the activation of L-type calcium currents, relieving intracellular Ca^2＋ overload, promoting Bcl-2 expression, and inhibiting Bax activation. The effect of curcumin was identical to nimodipine, suggesting that curcumin has the same neuroprotective effects against gp120 V3 loop-induced neuronal damage.

关 键 词：neural regeneration traditional Chinese medicine CURCUMIN gp120 V3 loop humanimmunodeficiency virus-1 associated neurocognitive disorders Ca^2＋ SYNAPSE apoptosis grants-supported paper NEUROREGENERATION 

分 类 号：R285.5[医药卫生—中药学]