线栓法制备大鼠局灶性脑缺血模型及其影响因素  

Thread occlusion for focal cerebral ischemia model preparation and its influential factors

作　　者：王荣森[1] 王舒[2] 沈燕[2] 

机构地区：[1]天津中医药大学研究生院,天津医学硕士研究生300110 [2]天津市针灸研究所,天津300193

出　　处：《医学研究生学报》2013年第5期520-523,共4页Journal of Medical Postgraduates

基　　金：国家973重点基础研究发展计划(2012CB518505);国家自然科学基金(81173339);天津市应用基础及前沿技术研究计划重点项目(11JCZDJC19800);长江学者和创新团队发展计划资助

摘　　要：在缺血性脑病的研究中,局灶性脑缺血模型的制备必不可少。用线栓阻塞大脑中动脉被公认为是较理想的造模方法,已得到广泛的研究和应用,并涌现出大量改良方法,但实施中也存在诸多分歧和影响因素。由于实验研究的需要,文中就模型的制备流程、影响因素及其现状进行综述,力求获得比较全面而清晰的认识。The preparation of a focal cerebral ischemia model is essential in the research of ischemic encephalopathy. Among the modeling methods, middle cerebral artery occlusion （MCAO） with thread is an ideal one, which has been widely studied and applied, and many modified methods have been developed as well. Meanwhile, there are also many controversial ideas and influential factors in their application. For need of experimental researches, this article presents an overview on the preparation process of the focal cerebral ischemia model, its influential factors and status quo, aiming at a clearer and more comprehensive understanding them.

关 键 词：大鼠 脑缺血模型 线栓法 大脑中动脉闭塞 

分 类 号：R743[医药卫生—神经病学与精神病学]