α-硫辛酸对腔隙性脑梗死伴糖尿病患者认知功能的影响  

Effects of Alpha-lipoic Acid on Congnitive Function in Lacunar Infarction Patients with Diabetes Mellitu

作　　者：丛文东[1] 吴达荣[1] 曾佳[1] 高展[1] 

机构地区：[1]深圳市龙岗中心医院神经内科,深圳518116

出　　处：《数理医药学杂志》2013年第3期281-283,共3页Journal of Mathematical Medicine

摘　　要：目的:观察腔隙性脑梗死伴糖尿病患者的认知功能损害特点,并探讨α-硫辛酸对其认知功能的影响。方法:伴有糖尿病的腔隙性脑梗死患者60例,随机分配在A组(30例,每天静脉使用α-硫辛酸)和B组(30例,一般治疗)中,对照组(30例)选用健康体检人群。使用蒙特利尔认知评估量表(MOCA)分别对两组患者在发病后3天、3个月进行认知功能评估,并分别与正常对照组进行比较。结果:在脑梗死发病后3天,两组患者均出现视空间与执行功能、命名、延迟记忆、注意力和计算能力、语言、定向功能障碍,总分与对照组相比差异有显著性。在发病后3个月,使用硫辛酸组各项评分较一般治疗组高,总分及注意力、视空间与执行功能、定向力差异有统计学意义。结论:在伴有糖尿病的腔隙性脑梗死患者急性期认知损害广泛,α-硫辛酸对认知功能具有保护作用。Objective： To explore the characters of cognitive dysfunction for lacunar infarction （L I） with diabetes mellitus and the protective effects of alpha -lipoic acid. Methods： A total of 64 LI patients with dia- betes mellitus randomly divided into 2 groups. Patients of group 1 （n=30） were treated with alpha -lipoic acid. Patients of group 2（n=30） were assigned conventional therapy. The cognitive function of patients were evaluated with Montreal Cognitive Assessment （MOCA） at 3days and 3months after attack. An additional control group consisted of age-matched healthy （n=30）. Results： Compared with controls, significant differ- ence was found on the memory, name, language, orientation, attention, executive function, visuospatial and visuo-constructive function at 3 days. Most cognitive domains were improved at 3 months of group 1, scores of general MoCA, attention, visuospatial and visuo-constructive function and orientation were higher than those of group 2 （P〈0. 05）. Conclusions： In acute stage of LI, the cognitive impairment was extensive and severe, alpha -lipoic acid may improve congnitive function.

关 键 词：Α-硫辛酸 2型糖尿病 腔隙性脑梗死 蒙特利尔认知评估量表 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R587.1[医药卫生—临床医学]