STAT3和CD34在胃癌早期诊断中的价值  

Study on the significance of STAT3 and CD34 in the early diagnosis of gastric cancer

作　　者：席银雪 黄丽清 许乙威 马东升 王建蔚 郑坚 黄希帆 许建平 

机构地区：[1]深圳市龙岗区第二人民医院,深圳518112

出　　处：《中国医师杂志》2013年第5期586-589,共4页Journal of Chinese Physician

基　　金：广东省科技厅社会发展领域科技计划项目（粤科社字[2011]106号）;深圳市科技计划项目（201103227）

摘　　要：目的探讨信号转导和转录活化因子3（Signal transduction and transcription activation factor3，STAT3）和CD34在胃癌发生发展中的表达及意义。方法选取2006年1月至2011年12月本院病理科标本120例。按诊断分慢性胃炎组、肠型化生组、不典型增生组、胃癌组，每组30例。并用免疫组化法检测各组STAT3和CD34的表达。结果慢性胃炎组、肠型化生组、不典型增生组、胃癌组STAT3阳性表达率分别为16．67％、93．33％、83．33％、86．67％；慢性胃炎组与肠型化生组、不典型增生组、胃癌组之间差异均有统计学意义（X^2=157．55，133．33，59．80，P〈0．01）；肠型化生组、不典型增生组、胃癌组之间差异无统计学意义（P〉0．05）。慢性胃炎组CD34表达的微血管密度（MVD）为13．01±9．19，肠化生组为13．09±9．37，不典型增生组为21．38±8．51，胃癌组为28．64±8．62；慢性胃炎组、肠型化生组与不典型增生组、胃癌组之间比较差异均有统计学意义（P〈0．01）；慢性胃炎组与肠型化生组之间差异无统计学意义（P〉0．05），不典型增生组与胃癌组差异无统计学意义（P〉0．05）。结论STAT3表达明显升高与胃癌的发生、发展有关，CD34增加与胃癌的发生有关；联合检测STAT3和CD34的表达情况有助胃癌的早期诊断。Objective To investigate the expression and significance of signal transduction and transcription activation factor 3 （STAT3） and CD34 in gastric carcinogenesis. Methods Pathological tis- sue specimens was collected in the Department of Pathology, The Second Peopleg Hospital, Shenzhen from January 2006 to December 2011. According to the pathological diagnosis, four groups were set up including chronic gastritis, intestinal metaplasia, displasia, and gastric cancer groups （ n = 30 cases/goup）. STAT3 and CD34 were detected by immunohistochemistry. Results The positive expression rates of STAT3 were 16.67% in the chronic gastritis group, 93.33% in the intestinal metaplasia group, 83.33% in the displa- sin group, and 86.67% in the gastric cancer group with a statistically significant difference among four groups （ X^2=157.55,133.33,59.80, P 〈0.01 ） , and, however, without statistically significant difference among the intestinal metaplasia, displasia, and gastric cancer groups （ P 〉 0.05 ）. The expressions of CD34 were 13. （11± 9.19 in the chronic gastritis group, 13.09 ± 9.37 in the intestinal metaplasia group, 21.38±8.51 in the displasia group, and 28.64 ± 8.62 in the gastric cancer group. The microvascular den- sity showed a statistically significant difference among four groups （ P 〈0.01 ） ; however, no difference was found between the chronic gastritis and intestinal metaplasia groups （ P 〉0. 05 ） and between the dis#asia and gastric cancer groups （ P 〉 0.05 ） . Conclusions The expressions of STAT3 were increased signifi- cantly, and were related to the occurrence and development of gastric cancer. The increased microvascular density was related to the occurrence of gastric cancer. The combination of expression changes of STAT3 and CD34 will benefit the early diagnosis of gastric cancer.

关 键 词：反式激活因子类 代谢 抗原 CD34 分析 胃肿瘤 诊断 胃肿瘤 病理学 

分 类 号：R735.2[医药卫生—肿瘤]