谷胱甘肽预防奥沙利铂神经毒性的疗效观察  

Efficacy of glutathione in prevention of neurotxicity induced by oxaliplatin

作　　者：于红[1] 嵇钧安 马长华[1] 

机构地区：[1]赣榆县人民医院肿瘤科,江苏赣榆222100

出　　处：《现代肿瘤医学》2013年第6期1342-1343,共2页Journal of Modern Oncology

摘　　要：目的:评价谷胱甘肽对奥沙利铂神经毒性的防治疗效[1]。方法:87例奥沙利铂全身化疗的肿瘤患者随机分为2组,治疗组44例(男性36例,女性8例),年龄为22-75岁,平均年龄为48岁;对照组43例(男性35例,女性8例),年龄为19-70岁,平均年龄为45岁。治疗组奥沙利铂化疗前2天,使用谷胱甘肽1200mg加入5%GS 250ml,静滴,每日一次,至化疗结束后3-5天;对照组予以保肝对症治疗,不使用谷胱甘肽。结果:治疗组奥沙利铂神经毒性发生率11.36%(5/44),对照组为51.16%(22/43),治疗组与对照组比较,差异有统计学意义(P<0.05)。结论:谷胱甘肽对预防奥沙利铂的神经毒性有较好效果,值得临床推行。Objective： To evaluate the effect of glutathione on the neurotoxicity induced by oxaliplatin.Methods： Eighty seven patients treated with oxaliplatin were randomly divided into two groups.The prevetion therapy group included 44（36 males and 8 females） aged from 22 to 75 years old with the average age of 48 years old.The control group included 43 patients（35 males and 8 females）.Aged from 19 to 70 years old with average age of 45.The patients in the prevention therapy group were intravenously infused reduced glutathione in 250ml,of 5% glucose solution at 1200mg / d,at 2 day before chemotherapy and lasted for 3-5 days postchemotherapy.The patients in the conrol troup were given conventional liver-protection therapy only.They did not receive glutathione treatment.Results： The rates of neurotoxicity in two groups were 11.36%（5 /44）,51.16%（22 /43）,and had significant difference（P 0.05）.Conclusion： Glutathione has good effects in prevention of neueurotoxicity induced by oxaliplatin and is worthy of application and popularization in clinical practice.

关 键 词：谷胱甘肽 奥沙利铂 神经毒性 

分 类 号：R730[医药卫生—肿瘤]