口腔鳞状细胞癌microRNA参与p53调控网络的相关研究  

Research progress of microRNA involved in p53 gene regulatory networks in oral squamous cell carcinoma(OSCC)

作　　者：王欣[1] 张圃[2] 任英红 焦军全[1] 

机构地区：[1]商洛市中心医院,肿瘤诊疗中心,陕西商洛726000 [2]第四军医大学口腔医学医院,颌面肿瘤外科,陕西西安710032

出　　处：《现代肿瘤医学》2013年第6期1372-1375,共4页Journal of Modern Oncology

基　　金：国家科技部"十一五"科技支撑计划项目(编号:2007BAI180B03);陕西省科技发展(公关)计划项目(编号:2009K-03)

摘　　要：p53基因突变几乎是各种肿瘤致病的关键因素,microRNA参与肿瘤的发生也已经被实验证实,目前关于口腔鳞癌中p53与microRNA具体的调控机制尚不完全清楚。本文就p53与microRNA存在的可能调控模式及口腔鳞癌p53和microRNA功能与表达方面的影响进行了综述。Mutations in the p53 pathway are found in nearly all types of cancers.Numerous studies were undertaken to successfully provide evidence for an involvement of microRNAs in cancer formation.The connection of mechanism between p53 and the miR genes is unclear.The regulation patters and expression and function of microRNA and p53 genes in oral squamous cell carcinoma is summarized here.

关 键 词：口腔鳞状细胞癌 MICRORNA P53 

分 类 号：R739.85[医药卫生—肿瘤]