Effects of zinc-substituted nano-hydroxyapatite coatings on bone integration with implant surfaces  

作　　者：Shi-fang ZHAO Wen-jing DONG Qiao-hong JIANG Fu-ming HE Xiao-xiang WANG Guo-li YANG 

机构地区：[1]Department of Oral Implantology,Affiliated Stomatology Hospital,School of Medicine,Zhejiang University

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2013年第6期518-525,共8页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：Project supported by the National Natural Science Foundation of China (No. 81000462);the Zhejiang Provincial Natural Science Foundation (No. R2110374),China

摘　　要：Objective:The purpose of this study was to investigate the effects of a zinc-substituted nano-hydroxyapatite(Zn-HA) coating,applied by an electrochemical process,on implant osseointegraton in a rabbit model.Methods:A Zn-HA coating or an HA coating was deposited using an electrochemical process.Surface morphology was examined using field-emission scanning electron microscopy.The crystal structure and chemical composition of the coatings were examined using an X-ray diffractometer(XRD) and Fourier transform infrared spectroscopy(FTIR).A total of 78 implants were inserted into femurs and tibias of rabbits.After two,four,and eight weeks,femurs and tibias were retrieved and prepared for histomorphometric evaluation and removal torque(RTQ) tests.Results:Rod-like HA crystals appeared on both implant surfaces.The dimensions of the Zn-HA crystals seemed to be smaller than those of HA.XRD patterns showed that the peaks of both coatings matched well with standard HA patterns.FTIR spectra showed that both coatings consisted of HA crystals.The Zn-HA coating significantly improved the bone area within all threads after four and eight weeks(P<0.05),the bone to implant contact(BIC) at four weeks(P<0.05),and RTQ values after four and eight weeks(P<0.05).Conclusions:The study showed that an electrochemically deposited Zn-HA coating has potential for improving bone integration with an implant surface.Objective：The purpose of this study was to investigate the effects of a zinc-substituted nano-hydroxyapatite（Zn-HA） coating,applied by an electrochemical process,on implant osseointegraton in a rabbit model.Methods：A Zn-HA coating or an HA coating was deposited using an electrochemical process.Surface morphology was examined using field-emission scanning electron microscopy.The crystal structure and chemical composition of the coatings were examined using an X-ray diffractometer（XRD） and Fourier transform infrared spectroscopy（FTIR）.A total of 78 implants were inserted into femurs and tibias of rabbits.After two,four,and eight weeks,femurs and tibias were retrieved and prepared for histomorphometric evaluation and removal torque（RTQ） tests.Results：Rod-like HA crystals appeared on both implant surfaces.The dimensions of the Zn-HA crystals seemed to be smaller than those of HA.XRD patterns showed that the peaks of both coatings matched well with standard HA patterns.FTIR spectra showed that both coatings consisted of HA crystals.The Zn-HA coating significantly improved the bone area within all threads after four and eight weeks（P〈0.05）,the bone to implant contact（BIC） at four weeks（P〈0.05）,and RTQ values after four and eight weeks（P〈0.05）.Conclusions：The study showed that an electrochemically deposited Zn-HA coating has potential for improving bone integration with an implant surface.

关 键 词：ZINC Hydroxyapatite coating Electrochemical process OSSEOINTEGRATION IMPLANT 

分 类 号：R783[医药卫生—口腔医学]