血清HE4和CA125联合检测在卵巢癌早期诊断的临床价值  

The clinical value of the HE4 combined with CA125 in the early diagnosis of the ovary cancer

作　　者：郑丽娥[1] 曲军英[1] 

机构地区：[1]福建医科大学附属第一医院妇产科,福建福州350005

出　　处：《中国医药科学》2013年第10期23-25,共3页China Medicine And Pharmacy

摘　　要：目的探讨HE4、CA125单独和联合检测,在卵巢癌诊断及疾病转归中的价值,探讨HE4水平与卵巢癌病理分型的关系,而且与肿瘤分期的相关性。方法应用ELISA法检测血清中HE4水平,应用电化学发光法检测血清CA125水平,其中卵巢癌的妇女40例、卵巢良性肿瘤30例、卵巢子宫内膜异位囊肿30例、健康妇女40例,比较各组的水平差异。结果在卵巢癌组血清HE4及CA125水平明显高于其他各组,差异均有统计学意义(P<0.05)。血清HE4在卵巢子宫内膜异位囊肿组与健康妇女组水平比较差异无统计学意义;但CA125在异位囊肿组水平却明显升高,与健康妇女组比较差异有统计学意义;卵巢癌组术前血清HE4水平与年龄相关,与病理分级、临床分期密切相关;经过全面卵巢癌分期手术患者术后血清HE4水平明显低于术前,差异有统计学意义(P<0.05);以健康妇女、卵巢良性疾病作参考人群,血清HE4水平在67 pmol/L时,为最佳界值点。HE4诊断卵巢癌的ROC-AUC为0.969,敏感度为92.5%特异度为98%。联合HE4及CA125检测,敏感度最高。结论 HE4是敏感的卵巢癌肿瘤标志物,敏感性较CA125高,联合检测有利于提高卵巢癌的诊断效率,血清HE4可以作为卵巢癌术后病情监测及临床转归的敏感血清标志物。Objective To observe the value of early diagnosis and sequelae of the combined and separated detection of HE4 and CA125 in ovary cancer.To discuss the relationship between HE4 and the pathologic type of the ovary cancer, and tumor staging. Methods ELISA was used to detect the level of HE4 in the serum and the electrochemiluminescence immunoassay （ ECLIA ） was used to detect the level of CA125.40 clinical cases of ovary cancer,30 clinical cases of benign ovary tumor,30 clinical cases of endometriosis and 40 clinical cases of healthy women were collected in order to compare the difference between those groups. Results The serum level of HE4 and CA125 in the group of ovary cancer was markedly higher than in other groups（P 〈 O.05）.The difference of serum level of HE4 in the groups of ovary endometriosis cyst and healthy women did not have a statistical meaning,but the level of CA125 in the ovary endometriosis cyst was high,if compared to the healthy women the difference had the statistical meaning. In the group of the ovary cancer, the level of HE4 before the operation was related to the patient age,and was positively related to the pathologic grading and clinical staging .The whole patients who undergo the ovary cancer surgical staging,after the surgical operation the level of HE4 was markedly lower than the level of HE4 before the operation（P 〈 0.05）.In the healthy women,the population of reference for the benign diseases of the ovary,when the serum level of HE4 is 67pmol/L,it was the best limit point value. The ROC-AUC for diagnosing the ovary cancer was 0.969,the sensitivity was 92.5%,the specificity was 98% .The combined detection of HE4 and CA125 had the highest sensitivity. Conclusion HE4 is a sensitive biomarker for diagnosing the ovary cancer.Its sensitivity is higher than the sensitivity of CA125. The combined detection of HE4 and C125 is more effective in diagnosing the ovary cancer. The serum HE4 can be used as the sensitive serum biomarker for detecting the clinical sequelae and the statu

关 键 词：人附睾蛋白4 CA125 卵巢癌 早期诊断 

分 类 号：R737.31[医药卫生—肿瘤]