听觉P300认识电位在多梗死性痴呆诊断中的价值定量研究  

Quantitative study on diagnosis value of auditory cognitive potential P300 in multiple infarctive dementia

作　　者：徐存理[1] 李宪章[1] 柴修良 李继峰[1] 程刚[1] 

机构地区：[1]济宁医学院附属医院神经内科,272029

出　　处：《中华物理医学与康复杂志》2000年第3期136-138,共3页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：山东省教委资助!项目(J9K43)

摘　　要：目的　对多梗死性痴呆 (MID)患者进行神经心理学及P30 0检查 ,分析P30 0在MID诊断中的价值。方法　应用神经心理学量表及P30 0检测MID组、多发性脑梗死非痴呆对照 (MI)组、正常对照(NC)组 ,分别测得简易精神状态检测量表 (MMSE)、长谷川智能检查量表 (HDS)、日常生活能力量表(ADL)及P30 0潜伏期和波幅结果。结果　NC组P30 0潜伏期 95 %正常范围的正常值为 2 87.2 4～ 374.86ms。MID组与MI及NC组比较 ,潜伏期明显延长 ,波幅减低 ,有非常显著性差异 (P <0 .0 1) ;MI与NC比较 ,虽然潜伏期延长 ,波幅下降和波形不规则 ,但均无统计学意义 (P >0 .0 5 ) ;P30 0潜伏期与MMSE、HDS、ADL呈负相关。结论　P30 0有助于诊断MID及严重程度 ,是MID诊断的客观指标。Objective To test P300 and neuropsythology in patients with multiple infarted dementia (MID) and to study the value of P300 in MID diagnosis.Methods The results of mini-mental state examination(MMSE),Hasegawa dementia scale for the age(HDS),activity of daily living scale(ADL) and latency of P300 with its amplitude were measured by neuropsychological scale and P300 in MID,myocardial infarction (MI) and mormal control (NC) groups.Results The 95 percent normal range of latency of P300 was between 287.24 and 374.86 ms,latency of in MID group was obviously longer and amplitude became shorter than those in MI and NC groups and the difference is dramatic(P< 0.01 );contrast with NC group,although latency of became longer,amplitude decreased and wave types were irregular in MI group,with no statistic value (P> 0.05 ).There is negative correlation between the results of latency of P300 and MMSE,HDS,ADL.Conclusion P300 is useful in the diagnosis of MID and its severity.It is an objective item in the dignosis MID.

关 键 词：脑梗塞 痴呆 多发性梗塞性 事件相关电位 P300 

分 类 号：R749.1[医药卫生—神经病学与精神病学]