基质金属蛋白酶-2和CD105在胃癌中的表达及其相关性的研究  

Expression and relationship of matrix metailoproteinase-2 and CD105 in gastric carcinoma

作　　者：闫永刚[1] 刘爱东[2] 苏经题[2] 李德艳[2] 

机构地区：[1]唐山钢铁集团有限责任公司医院泌尿外科,河北063000 [2]唐山职业技术学院医学院病理教研室

出　　处：《临床外科杂志》2013年第5期352-354,共3页Journal of Clinical Surgery

基　　金：河北省教育厅高等学校科学研究计划课题资助项目（Z2011317）;唐山市科学技术研究与发展计划课题资助（10130269c）

摘　　要：目的 检测基质金属蛋白酶-2（Matrix metalloproteinase-2,MMP-2）及CD105标记的血管密度（microvessel density,MVD）在胃癌中的表达,探讨二者在胃癌发生发展及转移中的作用.方法 采用免疫组织化学方法,分别检测MMP-2和CD105标记的微血管密度在不同临床病理特征之间的关系.结果 胃癌组织中MMP-2表达阳性率为66.7%,明显高于正常胃黏膜组织,胃癌中的血管密度明显高于正常胃黏膜组织,MMP-2及血管密度在胃癌中的表达均与分化程度、浸润深度及淋巴结转移有关,MMP-2阳性的血管密度明显高于阴性组.结论 MMP-2和CD105参与胃癌的发生和进展,MMP-2能促进胃癌中CD105阳性的血管生成.Objective To detect the expression of matrix metalloproteinase-2 （MMP-2）and mierovessel density （ MVD ） marked by CD105 in gastric carcinoma and investigate their relation in pathogenesis, development and metastasis in primary gastric carcinoma. Methods The expression of MMP-2 and MVD was detected in tissues with different pathological characters by immunological histological chemistry. Results The positive rate of MMP-2 expression in gastric carcinoma was 66.7%, which was signifiantly higher than that in the normal gastric tissues. The MVD in gastric carcinoma was upregulated compared with the normal tissues. The expression of MMP-2 and MVD in gastric carcinoma was correlated with differentiation,penetrating depth and lymph node metastasis. The MVD was upregulated in tissues with positive MMP-2 expression compared with the controls. Conclusion MMP-2 and CD105 may be involved in the occurrence and development of gastric carcinoma. MMP-2 can promote the angiogenesis which expresses CD105 in gastric carcinoma.

关 键 词：胃癌 MMP-2 CD105 血管生成 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]