药物中间体2-(2'-羟基-4'-氨基苯基)苯并噻唑的合成工艺改进  

Improved Synthesis Technology of Drug Intermediate 2-(2-Hydroxy-4′-Aminophenyl) Benzothiazole

作　　者：陈卓[1] 陈研明[2] 

机构地区：[1]西安医学院药学院,陕西西安710021 [2]西安交通大学医学院,陕西西安710049

出　　处：《中国药业》2013年第10期35-36,共2页China Pharmaceuticals

摘　　要：目的改进2-(2'-羟基-4'-氨基苯基)苯并噻唑的合成工艺。方法以邻氨基苯硫酚与对氨基水杨酸为原料,对该反应的合成方法进行改进。结果将反应收率由50%提高至81.7%,反应温度由150℃降至50℃,反应时间由3 h缩短至45 min。结论改进工艺既降低了成本,又增加了反应的环境友好性。Objective To improve the synthesis technology of 2- （2-Hydroxy-4＇-aminophenyl） benzothiazole. Methods With o- amino- thiophenol and aminosalicylate as the raw materials,the synthesis method was improved through etherification and Vilsmeier re- action. Results The reaction yield rate was increased from 50% to 81.7% ,the reaction temperature was decreased from 150 ℃to mild 50℃ ,and the reaction time was shortened from 3 h to 45 min. Conclusion The improved technology not only reduces the cost, but also increases the environmental friendliness of the reaction.

关 键 词：2-(2'-羟基-4'-氨基苯基)苯并噻唑 三甲基氯硅烷 合成工艺 

分 类 号：R914.5[医药卫生—药物化学] R981[医药卫生—药学]