食管癌患者的病理特征与组织中MIF表达的相关性研究  

The correlational study of pathological features and MIF expression in patients with esophageal cancer

作　　者：夏仙根[1] 

机构地区：[1]成都市第五人民医院病理科,四川成都611130

出　　处：《四川医学》2013年第4期450-452,共3页Sichuan Medical Journal

摘　　要：目的探讨巨噬细胞移动抑制因子(MIF)在食管癌组织中的表达,及其与食管癌的临床病理特征的相关性。方法收集80例原发性食管癌,采用免疫组织化学法检测其癌组织和癌旁食管上皮组织中MIF的表达。结果组织MIF阳性表达在食管癌组明显高于癌旁组织组,差异有统计学意义(P<0.05);MIF的表达和食管癌病理类型、肿瘤直径、肿瘤部位及分化程度等无明显相关(P>0.05),但与肿瘤临床TNM分期有关(P<0.05)。结论 MIF在食管癌组织中高表达,与肿瘤的临床TNM分期相关,可作为一种食管癌的诊断、预后评估和治疗的检测指标。Objective To investigate the expression of macrophage migration inhibitory factor（MIF） in esophageal cancer, and the correlation with clinical pathological features of esophageal cancer. Methods Immunobistochemistry were used to assay MIF expression of carcinoma tissue and the esophagus epithelium of the tumor-adjacent, tbr 80 cases of primary esophageal cancer. Results MIF positive expression in esophageal cancer group is obviously higher than that of the tumor-adjacent tissues group, the difference was statistically significant （ P 〈 0. 05 ）. MIF expression and esophageal cancer pathological type, tumor size, tumor site and differentiation degree had no obvious correlation （ P 〉 0. 05 ）. However, with clinical TNM staging related （P 〈 0. 05）. Conclusion MIF was high expression in esophageal cancer, with tumor clinical TNM staging related, it can be used testing indexes for esophageal cancer＇s diagnosis, prognosis and treatment.

关 键 词：巨噬细胞移动抑制因子 食管癌 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]