四联疗法和三联疗法根除幽门螺杆菌感染疗效研究  

Clinical effects of quadruple and triple chemotherapy for the treatment with eradication of helicobacter pylori(HP)

作　　者：代小松[1] 张莉[1] 

机构地区：[1]四川省医学科学院.四川省人民医院干部科,四川成都610072

出　　处：《四川医学》2013年第4期491-493,共3页Sichuan Medical Journal

摘　　要：目的对比含呋喃唑酮及胶体果胶铋的四联疗法和经典三联疗法对幽门螺杆菌(HP)根除的疗效。方法选择有HP感染的消化性溃疡、慢性胃炎伴胃粘膜糜烂萎缩的患者96例,随机均分为治疗组和对照组。治疗组选择埃索美拉唑+阿莫西林+呋喃唑酮+胶体果胶铋四联疗法,疗程7d;对照组选择埃索美拉唑+阿莫西林+克拉霉素经典三联疗法,疗程7d。观察HP的根除率和不良反应情况。结果含呋喃唑酮及胶体果胶铋的四联疗法与经典三联疗法均取得较好的根除率,分别为87.5%、81.3%,差异无统计学意义(P>0.05)。药物不良反应发生率差异无统计学意义(P>0.05)。结论含呋喃唑酮及胶体果胶铋的四联疗法根除幽门螺杆菌感染安全、有效。Objective Clinical study comparison the effects of furaxone and pectin bismuth-based quadruple chemotherapy and triple chemotherapy for the treatment eradication of helicohacter pylori（HP）. Methods 96 patients with HP infection accompanied with peptic ulcer or chronic gastritis with gastric mucosal erosion or atrophy were randomly divided into treatment group and control group. The patients in treatment group were given esomeprazole,amoxicillin, furaxone and pectin bismuth for 7 days, while in control group received esomeprazole, amoxicillin and clarithromycin. The condition of HP eradication and sideeffects were erahuated. Results The two therapies were effective and safe. The eradication rates of HP in treatment group were not significantly higher than that in control group（87.5% vs 81.3% ） （P 〉0.05）. The incidences of adverse reaction were no significant difference （P 〉 0. 05 ）. Conclusion The quadruple therapy of esomeprazole, amoxicillin, furaxone and pectin bismuth is a safe and effective choice for HP eradication.

关 键 词：呋喃唑酮 胶体果胶铋 幽门螺杆菌 四联疗法 三联疗法 

分 类 号：R57[医药卫生—消化系统]