18F—FDGPET／CT对偶发垂体大腺瘤的诊断价值  

The value of 18F-FDG PET/CT in the diagnosis of incidental pituitary macroadenoma

作　　者：李建南[1] 解敬慧[1] 杜雪梅[1] 陆陟[1] 刘静红[2] 林尚坤[1] 张延军[1] 

机构地区：[1]大连医科大学附属第一医院核医学科,116011 [2]大连医科大学附属第一医院放射科,116011

出　　处：《国际放射医学核医学杂志》2013年第3期172-176,共5页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：【摘要】目的研究偶发垂体大腺瘤在健康人群及肿瘤患者问发病率的差异，并探讨”F-FDGPET／CT全身显像在偶发垂体大腺瘤诊断中的临床意义。方法对行PET／CT头部及体部检查的无垂体瘤相关病史的1830例患者进行回顾性分析，其中健康体检者600例，确诊及疑诊肿瘤患者1230例；选择PET显示垂体部位高摄取及同机CT显示垂体占位（病灶短径大于1．0cm）患者，记录病灶最大标准化摄取值（SUV…）；对入选患者进行随访3～26个月，经病理及MRI明确最终诊断；所有结果采用SPSS16．0软件进行统计学分析，应用Fisher确切检验比较偶发垂体大腺瘤在两组人群间发病率的差异，并评价PET／CT对偶发垂体大腺瘤的诊断价值。结果15例患者符合上述标准入选，SUVmax为4．2．22．2；1例患者经手术确诊为垂体区转移瘤，SUVmax为195；14例患者为偶发垂体大腺瘤，发病率为0．77％，其中源于健康体检者1例，发病率为0．17％，其余13例患者均具有恶性肿瘤病史，发病率为1．06％；PET／CT对偶发垂体大腺瘤的检出率为100％，准确率为93．33％。结论恶性肿瘤患者组垂体大腺瘤的发病率高于健康体检组；18F—FDGPET／CT显像对偶发垂体大腺瘤具有较高的诊断价值。Objective To study the incidence difference between healthy people and patients with malignant tumor, and to discuss the diagnostic value of whole-body ISF-FDG PET/CT examination on inci- dental pituitary macroadenomas. Methods A review analysis was made about the image data of 1830 consecutive subjects with no history of pituitary tumor, including 600 healthy subjects and 1230 patients with known or suspected malignancy who underwent lSF-FDG PET/CT examination. The uptake intensity was recorded by maximum standardized uptake value （SUV,~） of those unexpected pituitary tumor （shot diame- ter greater than 1.0 cm） with high uptake. The final diagnosis was based on pathology and a 3-26 months follow-up. Compared the incidence difference between healthy people and patients with malignant tumor by Fisher exact test （SPSS 16.0）. Assessed the diagnostic efficacy of PET/CT examination. Results Pituitary tumor was accidentally discovered in 15 patients （SUVmax varied between 4.2 and 22.2）, including 1 metastases SUVmax 19.5 and 14 （0.77%） pituitary macroadenomas; the incidence rate 0.17% （only 1 case was confirmed of pituitary macroadenomas） among the healthy subjects is higher than that of 1.06% （13 cases） among the malignant tumor patients. The sensitivity and accuracy of PET/CT in detecting large pitu- itary adenomas were 100% and 93.33% respectively. Conclusions The incidence of pituitary macroadenoma is higher in patients with maligant tumor than that in the healthy controls. PET/CT is of practical significance in the diagnosis of the pituitary macroadenomas.

关 键 词：垂体肿瘤 正电子发射断层显像术 体层摄影术 X线计算机 氟脱氧葡萄糖F18 

分 类 号：R730.44[医药卫生—肿瘤]