胎儿染色体异常类型与妊娠结局的临床分析  

Clinical analysis of pregnancy outcome of fetus with abnormal karyotypes

作　　者：梁彩红[1] 禤洁甜[1] 林蔚[1] 汤丽霞[1] 杨光[1] 

机构地区：[1]广东省佛山市第一人民医院,528000

出　　处：《实用医技杂志》2013年第6期602-604,共3页Journal of Practical Medical Techniques

摘　　要：目的探讨产前诊断指征与胎儿染色体异常类型的关系,分析不同染色体异常胎儿的妊娠结局,为合理指导妊娠提供依据。方法选择我院产前诊断指征为高危的孕妇2 579例,行羊水或脐血染色体培养,分析染色体异常类型;以电话、病历采集等方式随访妊娠结局。结果 2 579例染色体检查结果中,异常核型97例,异常率为3.8%(97/2 579),其中数目异常60例,占62.9%(60/97);结构异常30例,占30.9%(30/97);嵌合体7例,占7.2%(7/97)。97例异常核型的胎儿,73例终止妊娠,24例继续妊娠。结论产前染色体检查可明确胎儿染色体的类型,合理指导妊娠,减少缺陷胎儿的出生。Objective To study the relationship between prenatal diagnosis indications and abnormal karyotypes, analyze the pregnancy outcome of fetus with abnormal karyotypes, and investigate the necessity to continue pregnancy. Methods 2 579 cases of high risk pregnant women were recruited in our genetic consultant department, amniotic fluid samples and umbilical blood samples were obtained for cell culture and karyotype analysis. Follow-up visit of pregnancy outcomes were also carried out by phone call or medical record collecting. Results Of the 2 579 cases, abnormal embryo karyotypes were identified in 97 cases （3.8%）. Of the abnormal karyotypes, 62.9%（60/97） were numerical abnormalities, 30.9%（30/97） were structural abnormalities, 7.2% （7/97） were structural abnormalities. Of all the chromosomal abnormal cases above, 73 choose to terminate pregnancy and 24 choose to continue pregnancy. Conclusion Karyotype analysis of the embryo in the pregnant women with prenatal diagnostic indicators might be helpful to identify the type of chromosome, guide the pregnancy, and reduce the incidence of birth defect.

关 键 词：产前诊断 染色体 核型分析 妊娠结局 

分 类 号：R714.5[医药卫生—妇产科学]