葡萄糖转运蛋白1在恶性胸腔积液中表达及意义  

Research on the Expression of GLUT-1 in malignant pleural effusion

作　　者：王秀蕊 张秀琴[2] 丁萌[2] 耿学丽[2] 

机构地区：[1]兴隆县人民医院检验科,河北承德067300 [2]承德医学院附属医院检验科,河北承德067000

出　　处：《国际检验医学杂志》2013年第10期1240-1241,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨葡萄糖转运蛋白-1(GLUT-1)在恶性胸腔积液中的表达水平及临床意义。方法健康对照组30例(C组)和70例胸腔积液患者[结核性胸腔积液30例(A组)、恶性胸腔积液40例(B组)],应用酶联免疫吸附法(ELISA)测定血清和胸腔积液中的GLUT-1水平,并进行比较。结果 A组血清中GLUT-1水平为0.568ng/mL(0.551～0.587ng/mL),B组血清中GLUT-1水平为0.565ng/mL(0.544～0.578ng/mL),均高于C组0.356ng/mL(0.340～0.360ng/mL,P<0.01),但A、B组间比较差异无统计学意义(P>0.05);A组胸腔积液中GLUT-1水平为0.884ng/mL(0.869～0.903ng/mL),B组胸腔积液中GLUT-1水平为1.057ng/mL(1.040～1.070ng/mL),均高于同组血清中的水平(P<0.01),且B组高于A组(P<0.01)。结论 GLUT-1在恶性胸腔积液中高表达,检测GLUT-1水平有助于良、恶性胸腔积液的诊断和鉴别诊断。Objective To investigate the expressions and clinical significance of glucose transporter-1（GLUT-1） in malignant pleural effusions.Methods The levels of GLUT-1 in Serum and pleural effusion were determined in 30 healthy controls（C group） and 70 patients with pleural effusions[tuberculosis pleural effusion 30 cases（A group） and malignant pleural effusion 40 cases（B group）] by using Enzyme-linked immunosorbent assay（ELISA）.Results The levels in serum of GLUT-1 in two pleural effusion groups were higher significantly than those in normal controlled group（P＆lt;0.01）,but no difference between the two groups（P＆gt;0.05）.The levels in pleural effusions of GLUT-1 in two groups were higher than those in serum（P＆lt;0.01）,and the level in malignant groups was significantly higher than that in tuberculosis group（P＆lt;0.01）.Conclusion GLUT-1 in malignant pleural effusion were high expressions,and it might be important for differentiating of benign and malignant pleural effusion in clinical.

关 键 词：单糖转运蛋白质类 胸腔积液 恶性 酶联免疫吸附测定 

分 类 号：R730.4[医药卫生—肿瘤]