正交设计优化石榴皮多酚凝胶剂的处方配比  

Formula of Punica granatum peel phenols gel by orthogonal design

作　　者：罗玉琴[1] 阿力木江·阿布力孜[1] 来海中[1,2] 阿吉艾克拜尔·艾萨[1] 

机构地区：[1]中国科学院干旱区植物资源化学重点实验室,省部共建新疆特有药用资源利用国家重点实验室培育基地,中国科学院新疆理化技术研究所,乌鲁木齐830011 [2]新疆莎菲雅生物科技有限责任公司,乌鲁木齐830013

出　　处：《新疆医科大学学报》2013年第6期734-736,共3页Journal of Xinjiang Medical University

基　　金：中国科学院西部行动计划项目(KZCX2-XB3-17)

摘　　要：目的优选石榴皮多酚凝胶剂的最佳处方配比。方法采用正交试验设计,以卡波姆-940、丙二醇用量、凝胶pH值为考察因素,以制剂的外观性状、涂展性、均匀性、离心性的综合评价为指标,筛选出最优处方。结果最优处方配比:卡波姆-940为1.0%,丙二醇为10%,pH为4.0～5.5。结论该凝胶剂制备工艺简单,方法可靠,稳定可行。Objective To This study is conducted search for the optimum formula of Punica granatum peel phenols gel. Methods by orthogonal design of L9 （3^4）, in which the factors of the concentration Car bopol-940, the dosage of propylene glycol and pH are considered, and appearance, spreadability, uniformity and centrifugal are taken as the evaluation indexes to optimize the formula. Results 1% of Carbopol- 940, 10% of propylene glycol and 4.0-5.5 of pH were the optimum formula. Conclusion The optimum formula of gel is simple, and the method is reliable, and the stability is good.

关 键 词：石榴皮 总多酚 凝胶剂 正交设计 

分 类 号：R94[医药卫生—药剂学]