电刺激小脑顶核对血管性痴呆认知功能及血液流变学的影响  

Effects of fastigial nucleus stimulation on cognitive function and blood rheology with vascular dementia

作　　者：陈松盛[1] 何娅[1] 袁平花[1] 

机构地区：[1]西安交通大学医学院第二附属医院老年神经内科,西安710004

出　　处：《陕西医学杂志》2013年第6期731-732,734,共3页Shaanxi Medical Journal

基　　金：西安交通大学医学院第二附属医院院科研基金资助课题(2001YJ-36)

摘　　要：目的:研究电刺激小脑顶核(CFN)对血管性痴呆认知功能及血液流变学的影响。方法:68例血管性痴呆患者随机分为治疗组和对照组,治疗组在常规治疗的基础上同时接受电刺激小脑顶核治疗,对照组仅给予常规治疗。观察两组患者的神经功能缺损评分、简易智能精神状态量表、日常生活能力及血液流变学指标的变化。结果:治疗组患者临床总有效率为94.29%,对照组78.79%,两组比较有显著性差异(P<0.05)。治疗组患者的神经功能缺损评分、MMSE评分、ADL评分均与对照组有显著性差异(P<0.05)。治疗组与对照组相比血液流变学指标的变化有显著性差异(P<0.05)。结论:电刺激小脑顶核能显著改善血管性痴呆患者的认知功能及血液流变学指标。血液流变学变化可能是其治疗机理之一。Objective： To investigate the effects of fastigial nucleus stimulation on the blood rheology with vascular dementia and explore the clinical significance. Methods..68 patients with vascular dementia were randomly into divided into treatment group（35 cases） and control group（33 cases）. The patients of treatment group had been treated with FNS on the base of routine medical treatment. The patients of control group had only been given base treatment. Finally,observe the blood rehology and the clinical curative effect. Results： The overall effective rate of treatment group was 94.29 %. The control group was 78.79 %. There were significant difference between two groups （P〈0.05）. After FNS treatment, there were significant difference of the blood rheology of patients between two groups and there were significant difference of the nervous score of patients between two groups （P〈0.05）. Conclusion：The FNS can improve evidently the clinical curative effect and the blood rheology with vascular dementia. Variation of the blood rheology could be one of system of treatment.

关 键 词：痴呆 血管性 小脑核 电刺激疗法 血液流变学 认知 

分 类 号：R743.9[医药卫生—神经病学与精神病学]