Synthesis, Micellization and Characterization of Novel Amphiphilic β-Cyclodextrin/Poly（L-aspartate） Copolymer  

作　　者：GUO Yan-ling CUI Zhao-shan HAN Min 

机构地区：[1]College of Science [2]College of Material Science and Chemical Engineering,Tianjin University of Science and Technology, Tianjin 300457, P. R. China

出　　处：《Chemical Research in Chinese Universities》2013年第3期603-606,共4页高等学校化学研究（英文版）

摘　　要：A novel amphiphilic β-cyclodextrin/poly（L-aspartate）（β-CD-PASP） copolymer was prepared by ringopening polymerization of polysuccinimide（PSI）. This copolymer bears β-CD units along the macromolecular chain and the structure was characterized by infrared（IR） and proton nuclear magnetic resonance（Ill NMR）. The molecular weight of the copolymer was determined by gel permeation chromatography（GPC）. The copolymer micelle were prepared by direct dissolution method. The critical micelle concentration（CMC） of the copolymer micelle was measured by flourescence technique with pyrene as probe. The size distribution of micelle was characterized on a dy- namic laser light scattering particle size analyzer and its shape was observed by transmission electron microscopy（TEM）. The results show that the copolymer could self-assemble into micelle with a low CMC, and the effective diameter of the micelle was 116.3 nm. The methotrexate（MTX）-loaded micelle were prepared and the drug loading content（DLC） was 22.86%. The MTX-loaded cooolvmer exhibited a better water-solubility than the free drug.A novel amphiphilic β-cyclodextrin/poly（L-aspartate）（β-CD-PASP） copolymer was prepared by ringopening polymerization of polysuccinimide（PSI）. This copolymer bears β-CD units along the macromolecular chain and the structure was characterized by infrared（IR） and proton nuclear magnetic resonance（Ill NMR）. The molecular weight of the copolymer was determined by gel permeation chromatography（GPC）. The copolymer micelle were prepared by direct dissolution method. The critical micelle concentration（CMC） of the copolymer micelle was measured by flourescence technique with pyrene as probe. The size distribution of micelle was characterized on a dy- namic laser light scattering particle size analyzer and its shape was observed by transmission electron microscopy（TEM）. The results show that the copolymer could self-assemble into micelle with a low CMC, and the effective diameter of the micelle was 116.3 nm. The methotrexate（MTX）-loaded micelle were prepared and the drug loading content（DLC） was 22.86%. The MTX-loaded cooolvmer exhibited a better water-solubility than the free drug.

关 键 词：Β-CYCLODEXTRIN AMPHIPHILIC MICELLIZATION METHOTREXATE 

分 类 号：TQ225.261[化学工程—有机化工] O632.13[理学—高分子化学]