长效抗癌植入剂抑制动物模型肿瘤生长活性研究  

Long-term Anti-cancer Implants Inhibiting the Activity of Tumor Growth in Animal Models

作　　者：于美丽[1] 杜智[1] 薛钧尘[1] 郭宏玥[1] 王若曦[1] 熊薇[1] 李澶[1] 

机构地区：[1]天津市第三中心医院天津市人工细胞重点实验室,天津300170

出　　处：《生物医学工程学杂志》2013年第3期552-555,共4页Journal of Biomedical Engineering

摘　　要：研究聚酸酐-吡柔比星(PAD-THP)长效抗癌植入剂在大鼠膀胱肿瘤动物模型体内的抑瘤作用。通过N-正丁基-N-(4-羟基-丁基)亚硝胺(BBN)喂饲构建大鼠膀胱肿瘤模型。将含药PAD-THP长效抗癌植入剂和相同剂量THP裸药分别置入大鼠膀胱肿瘤模型体内膀胱黏膜下,高效液相色谱(HPLC)检测体内THP血药浓度,观察比较动物体内有效药物浓度持续时间;分别测量治疗前后肿瘤大小,分析比较动物体内抑瘤效果。结果表明PAD-THP植入剂具有良好的药物局部缓释特性和明显的抑瘤效果;与相同剂量THP裸药组比较具有显著性差异(P<0.05)。预示PAD-THP抗癌植入剂在膀胱肿瘤的术后局部治疗方面具有良好的临床应用前景。This study was aimed to establish rat bladder tumor animal models to investigate the in vivo antitumor effect of polyanhydride-piraruhicin （PAD-THP）, a long-lasting anti-cancer implant, in the bladder tumor of animal models. The model of bladder cancer was set up with N-butly-N-（4 hydroxybutyl） nitrosamine （BBN） feeding into rats. The PAD-THP long-acting anti-cancer implants containing the drugs and the same dose of the THP naked drug were placed under the bladder mucosa of bladder tumor model in vivo. The pirarubicin plasma concentration was measured with high performance liquid chromatography （HPLC） detection in vivo. The effective drug concentration and lasting period were observed and compared in the animal bodies. The tumor sizes were measured before and after the treatment. The in vivo antitumor effects were analyzed and compared. The results showed that more significant antitumor effect of PAD-THP implants on the local drug release characteristics were presented compared with that of the same dose of THP bare drug group and there were significant differences （P〈0.05） between the two methods. All the results indicated that the PAD-THP anti-cancer implants in the postoperative local treatment of bladder tumors would show prosperous in the future for clinical application.

关 键 词：膀胱肿瘤治疗 聚酸酐-吡柔比星 抗癌植入剂 SD大鼠 

分 类 号：R737.14[医药卫生—肿瘤]